protein causing the erythrocyte to appear sickle shaped when viewed through a microscope. e. Draw a Punnett Square which show her father as having a heterozygous genotype for sickle cell and her mother has having a homozygous genotype for sickle cell anemia. Figure 1 Sickle Cell Anemia Punnett Square Father S Father s Mother s Ss Heterozygous carrier ss Homozygous affected Mother s Ss Heterozygous carrier ss Homozygous affected
5 Note. This figure displays the reproducing genetic outcomes between a heterozygous genotype father and a homozygous genotype mother (Jorde, 2019). S = dominant alleles; s = recessive alleles. f. What was this patient’s chance of having sickle cell trait? The sickle cell trait is carried on the recessive allele and must be a homozygous genotype for the disorder to express phenotypically, making it an autosomal recessive genetic disorder (Tanabe et al., 2019). A person with sickle cell trait will have a heterozygous genotype, one dominant allele and one recessive allele, with a normal phenotype (Jorde, 2019). This patient has a 50% chance of having the sickle cell trait. g. Based on the parent’s genotypes, which one has sickle cell trait, and which one has sickle cell anemia? The mother’s genotype is homozygous recessive causing sickle cell anemia to be expressed. The father has a heterozygous genotype for sickle cell anemia causing him to carry the trait but present phenotypically normal (Jorde, 2019).
- Fall '15
- pH, UTA, Zygosity, sickle cell trait, Phenylketonuria