Gangrene and limb amputations occur with continued use Brain infections and

Gangrene and limb amputations occur with continued

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Gangrene and limb amputations occur with continued use Brain infections and abcesses Cocaine/Psychostimulants Activate the sympathetic nervous system Elevate mood/ euphoric effect Alertness Fight or flight response Cocaine inhibits the re-uptake of synaptic dopamine Dopamine in Nucleus Accumbens Giving the reward signaling It also binds with high affinity to the serotonin transporter (SERT), and norepinephrine transporter (NET) Neurobiological Recovery Data If abstain for a significant amount of time, there is recovery in brain matter All participants performed a cognitive assessment battery and received an MRI which was analyzed using voxel-based morphometry Abstainers had significantly higher gray matter density than the current cocaine users in neocortical areas including the frontal and temporal cortex Within users and abstainers, cortical density was correlated with performance on memory and reaction time tasks. Subcortical gray matter density was lower in both the users and abstainers relative to the controls. These data suggest that individuals able to remain abstinent from cocaine for at least 1 month have elevated neocortical tissue density and perform better on multiple cognitive tests, relative to current cocaine users.
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  • Fall '12
  • MarciLobel
  • Cannabis, Recreational drug use, Cannabinoid receptor, Cannabinoid

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