Gangrene and limb amputations occur with continued use○Brain infections and abcesses Cocaine/Psychostimulants●Activate the sympathetic nervous system●Elevate mood/ euphoric effect●Alertness●Fight or flight response●Cocaine inhibits the re-uptake of synaptic dopamine ○Dopamine in Nucleus Accumbens○Giving the reward signaling●It also binds with high affinity to the serotonin transporter (SERT), and norepinephrine transporter (NET)Neurobiological Recovery Data●If abstain for a significant amount of time, there is recovery in brain matter●All participants performed a cognitive assessment battery and received an MRI which was analyzed using voxel-based morphometry ●Abstainers had significantly higher gray matter density than the current cocaine users in neocortical areas including the frontal and temporal cortex ●Within users and abstainers, cortical density was correlated with performance on memory and reaction time tasks. ●Subcortical gray matter density was lower in both the users and abstainers relative to the controls. ●These data suggest that individuals able to remain abstinent from cocaine for at least 1 month have elevated neocortical tissue density and perform better on multiple cognitive tests, relative to current cocaine users.
Cannabis, Recreational drug use, Cannabinoid receptor, Cannabinoid
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