Lecture 30 – Renal Physiology V

Of you just change plasma k levels you will still

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of you just change plasma K levels, you will still increase aldosterone – even without the  plasma angiotensin II (see flowchart above) the first pathway cannot be changed unless there is a Na concentration change Calcium Balance About 60% of the plasma Ca is available for glomerular filtration Rest is bound to proteins of complexed by anions Calcium is VERY highly regulated because of all the functions it has Only some of it circulates in the plasma Most of the calcium is in the bones, which is a reservoir Calcium is lad down in the bones by osteoblasts, deposit Ca in bones and osteoclasts  remove Ca from bones Tightly regulated Very active metabolic tissue
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More than 60% of Ca reabsorption is not under hormonal control and occurs in the  proximal tubule Not regulated, it just happens Remainder or reabsorption is under hormonal control and is regulated strictly Controlled by the parathyroid hormone and 125OH2D3 PTH is a peptide horkone, cannot cross cell membranes Made by the parathyroid glands in a response to a decrease in circulating Ca  Stimulates the reabsorption in the ascending limb of the loop of henle and in DT Stimulates activation of 125OD3 in the kidenys which stimulates Ca absorption in the  digestive tract and Ca reabsorption in the kidneys Stimulates the reabsorption of Ca from the bone 125OHD3 synthesizes from vitamin D acts to stimulate Ca absorption in the digestive tract and reabsorption in distal tubules of  kidney acts in the same direction as PTH Calcitonin is a peptide hormone that is secreted from C cells of the thyroid gland and  which acts to decrease plasma {ca] bt acting to increase the rate of bone deposition  (putting Ca into the bone from plasma) Decreases rate of calcium reabsorption in the kidneys Much bigger impact via bone deposition
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