But some months later dale and his colleague dudley

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But some months later, Dale and his colleague Dudley found acetylcholine in the mammalian body when they were trying to find endogenous histamine 6. The eserinised leech muscle: the key to acetylcholine a. Further research was aided by Wilhelm Feldberg who brought the Leech test which revolutionized the analysis of acetylcholine i. Key of this test was the use of serine, which inhibited the activity of the enzyme acetylcholinesterase b. To further decrease any doubts, Dale contributed a communication, introducing the terms cholinergic and adrenergic to designate nerve fibers by the nature of the chemical they used or might use, as a transmitter 7. Acetylcholine: beyond 1936 a. Some neurophysiologists, like John Eccles still opposed the idea of chemical neurotransmission and believe it its purely an electrical phenomenon b. But Eccles finally accepted the theory in 1951 c. The leech muscle assay remained the best way to analyze acetylcholine until the 1960s when more sophisticated methods of analysis were being developed 8. Conclusion
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