6 explain in detail at least 2 ways in which

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of the page but INDICATE so (or else a portion of your answer may be missed). 6. Explain in detail at least 2 ways in which stimulation of a receptor tyrosine kinase could lead to an increase in CREB-mediated transcription of a gene . (16 marks)
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Psychology 115: Neuropsychopharmacology—Spring 2011- Practice Exam Page 2 Answers: 1-T 2-F 3-T 4-D 5-A 6. This would be a perfectly organized answer agonist binds to RTK (0.5) Receptor dimerization (0.5) transphosphorylation or autophosphorylation on Tyr (0.5) activation of a small G protein (e.g. Ras) (1) recruitment/activation of PLC (1) activation of Raf (1) PIP2 (0.5) DAG (0.5) + IP3 (0.5) activation of MEK (1) IP3R (1) p-ERK (1) Ca from ER (1) p-ERK translocates to nucleus (0.5) Ca-Calmodulin (1) p-RSK (1) CaMK (1) p-CREB (1) CREB dimerization (0.5) & binding to CRE on DNA (1) Activation of RNA halozyme or RNA Polymerase II is also ok (1) NOTE: while PKC will be activated by the DAG that is generated by PLC activation, PKC does not directly phosphorylate CREB so the DAG PKC signal does not play a role in regulating CREB activity.
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  • Spring '13
  • Szumlinski
  • Psychology, 2011- Practice Exam, Neuropsychopharmacology—Spring 2011- Practice, receptor tyrosine phosphatases

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