{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}


6 explain in detail at least 2 ways in which

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
of the page but INDICATE so (or else a portion of your answer may be missed). 6. Explain in detail at least 2 ways in which stimulation of a receptor tyrosine kinase could lead to an increase in CREB-mediated transcription of a gene . (16 marks)
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Psychology 115: Neuropsychopharmacology—Spring 2011- Practice Exam Page 2 Answers: 1-T 2-F 3-T 4-D 5-A 6. This would be a perfectly organized answer agonist binds to RTK (0.5) Receptor dimerization (0.5) transphosphorylation or autophosphorylation on Tyr (0.5) activation of a small G protein (e.g. Ras) (1) recruitment/activation of PLC (1) activation of Raf (1) PIP2 (0.5) DAG (0.5) + IP3 (0.5) activation of MEK (1) IP3R (1) p-ERK (1) Ca from ER (1) p-ERK translocates to nucleus (0.5) Ca-Calmodulin (1) p-RSK (1) CaMK (1) p-CREB (1) CREB dimerization (0.5) & binding to CRE on DNA (1) Activation of RNA halozyme or RNA Polymerase II is also ok (1) NOTE: while PKC will be activated by the DAG that is generated by PLC activation, PKC does not directly phosphorylate CREB so the DAG PKC signal does not play a role in regulating CREB activity.
Background image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}