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____11.Isosorbide dinitrate is a long-acting nitrate given twice daily. The schedule for administration is 7 a.m. and 2 p.m. because:1.Long-acting forms have a higher risk for toxicity.2.Orthostatic hypotension is a common adverse effect.3.It must be taken with milk or food.4.Nitrate tolerance can develop.____12.Combinations of a long-acting nitrate and a beta blocker are especially effective in treating angina because:
____13.Drug choices to treat angina in older adults differ from those of younger adults only in:____14.Which of the following drugs has been associated with increased risk for myocardial infarction in women?____15.Cost of antianginal drug therapy should be considered in drug selection because of all of the following EXCEPT:1.Patients often require multiple drugs2.A large number of angina patients are older adults on fixed incomes3.Generic formulations may be cheaper but are rarely bioequivalent4.Lack of drug selectivity may result in increased adverse reactions____16.Situations that suggest referral to a specialist is appropriate include:____17.The rationale for prescribing calcium blockers for angina can be based on the need for: