MOA: inhibiting neurotransmitter GABA and inhibits neuronal activity within the brain and spinal cord Side/Adverse Effects: drowsiness; dizziness; weakness; fatique *Slowly wean medication in order to minimize: fevers, seizures, rebound muscle spasticity, hallucinations
AUTOIMMUNE DISORDERS Drug Class: Mixed opioid-nonopioid analgesic Prototype: tramadol MOA: binds to mu receptor and inhibits norepinephrine and serotonin reuptake in spinal neurons which inhibits transmission of pain impulses Side/Adverse Effects: vertigo; dizziness; HA; N/V; constipation; lethargy; CNS stimulation effects; drowsiness; depression Interactions: Antidepressants; MAOIs, CYP Contraindicated with St. John’s wort; caution with valerian or kava *Seizures have been seen in patients taking concurrently with antidepressants *Dependence may occur but less likely than that to morphine sulfate *Monitor for signs of withdrawl: anxiety, sweating, tremors, paresthesia *OVERDOSE can cause CNS depression, respiratory depression, and death
AUTOIMMUNE DISORDERS Drug Class: SNRI Serotonin-Norepinephrine Reuptake Inhibitor Prototype: venlafaxine MOA: inhibits the presynaptic neuronal reuptake of norepinephrine and serotonin in the CNS Side/Adverse Effects: nausea; wt loss; nervousness; insomnia; sedative effects; HA; emotional lability; HTN; sexual dysfunction in men and women; rectal/uterine/vaginal hemorrhage (rare) Interactions: CYP; herbal products Contraindicated with MAOIs (must stop MAOI 7 days prior); caution with cardiac, renal, hepatic impairment; Not to be given to those with bipolar disorder *Monitor EKG;RFP; LFT
AUTOIMMUNE DISORDERS Drug Class: SNRI Serotonin-Norepinephrine Reuptake Inhibitor Prototype: duloxetine MOA:inhibits the presynaptic neuronal reuptake of norepinephrine and serotonin in the CNS Side/Adverse Effects: abnormal vision most frequent; N/D; photosensitvity; bruising; anorexia; thrombophlebitis; constipation; dry mouth; anxiety; insomnia Interactions: Contraindicated:caution with pts who have hepatic/cardiac/renal impairment; HTN; mania; seizure disorders *Monitor LFTs/RFP/EKG
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- Spring '18
- AUTOIMMUNE, Prototype