Receiving NSAIDs and Related Agents Assess oKnown allergies to any salicylates

Receiving NSAIDs and Related Agents  Assess: o Known allergies to any salicylates, NSAIDs, or tartrazine o Baseline status before beginning therapy and for any potential adverse effects o Pregnancy or lactation; hepatic or renal disease; CV dysfunction; hypertension; and GI bleeding or peptic ulcer o Presence of any skin lesions; temperature; orientation, reflexes, and affect; pulse, blood pressure, and perfusion; respirations and adventitious sounds; liver evaluation; bowel sounds; and CBC, liver and renal function tests, urinalysis, stool guaiac, and serum electrolytes .  0002674835.INDD 12 4/11/2016 4:45:26 PM  Copyright ©

Copyright © 2017 Wolters Kluwer • All Rights Reserved Acetaminophen #1 Acetaminophen #1  Actions- o Acts directly on the thermoregulatory cells of the hypothalamus o Mechanism of action unknown but related to analgesic effects o Used to treat pain and fever  Treat pain and fever associated with a variety of conditions, including influenza  Prophylaxis of children receiving diphtheria–pertussis– tetanus (DPT) immunizations  Relief of musculoskeletal pain associated with arthritis

Copyright © 2017 Wolters Kluwer • All Rights Reserved Acetaminophen #2 Acetaminophen #2  Pharmacokinetics o Absorbed from GI tract o Peak ½ to 2 hours o Metabolized in the liver o Excreted in the urine  Contraindications- o Known allergy o Use with caution in pregnancy and lactation o Hepatic dysfunction or chronic alcoholism

Copyright © 2017 Wolters Kluwer • All Rights Reserved Acetaminophen #3 Acetaminophen #3  Adverse Reactions o Headache, hemolytic anemia, renal dysfunction, skin rash and fever o Hepatotoxicity usually associated with chronic use and overdose  Drug-to-Drug Interactions o Oral anticoagulants increase bleeding o Hepatotoxicity with barbiturates, carbamazepine, hydantoins, or rifampin

Copyright © 2017 Wolters Kluwer • All Rights Reserved Nursing Considerations for Patients receiving Acetaminophen Nursing Considerations for Patients receiving Acetaminophen  Assess- o Known allergies o Baseline status before beginning therapy and for any potential adverse effects o Pregnancy or lactation; hepatic or renal disease; CV dysfunction; hypertension; and GI bleeding or peptic ulcer o Presence of any skin lesions; temperature; orientation, reflexes, and affect; pulse, blood pressure, and perfusion; respirations and adventitious sounds; liver evaluation; bowel sounds; and CBC, liver and renal function tests, urinalysis, stool guaiac, and serum electrolytes.