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Blood types are determined by surface antigens on erythrocytes 3 alleles possible to code for type of glycoprotein on outside surface of RBC
BIOL 4160 Exam 3Problem with someone who is type A receiving type B blood?
BIOL 4160 Exam 3Activation of thrombocytes results in release of:*Thromboxane A2* - results in further aggregation of platelets to injured area – amplified signalADP– travels to normal endothelium cells on either side of injury – release prostacyclin and nitric oxide, which prevents formation/aggregation of platelets in normal tissue/endothelium o3 – Blood coagulation Platelet plug formation review Area of trauma exposes collagenVW circulating in plasma binds at that siteVW attracts thrombocytes to the site and activates them – now spiky matrices Activation of thrombocytes results in the release of:oThromboxane A2 – further aggregation of platelets at injured siteoADP – normal endothelium releases prostacyclin and nitric oxide, which prevents aggregation of platelets in normal tissue (targets platelet formation at area of injury) Medical relevance Aspirin Inhibits the formation of prostaglandins such as thromboxane A2 At risk of bleeding out oInhibiting clot formation NSAIDs (non-steroidal anti-inflammatory drugs) Also ibuprofen and acetaminophen – not as big of a problem as aspirinBlood clot formation