Blood types are determined by surface antigens on

Blood types are determined by surface antigens on erythrocytes
 3 alleles possible to code for type of glycoprotein on outside surface of RBC

BIOL 4160 Exam 3
 Problem with someone who is type A receiving type B blood?

BIOL 4160 Exam 3
 Activation of thrombocytes results in release of:
 *Thromboxane A2 * - results in further aggregation of
platelets to injured area – amplified signal
 ADP – travels to normal endothelium cells on either side of
injury – release prostacyclin and nitric oxide, which prevents
formation/aggregation of platelets in normal
tissue/endothelium
o 3 – Blood coagulation
Platelet plug formation review
 Area of trauma exposes collagen
 VW circulating in plasma binds at that site
 VW attracts thrombocytes to the site and activates them – now spiky matrices
 Activation of thrombocytes results in the release of:
o Thromboxane A2 – further aggregation of platelets at injured site
o ADP – normal endothelium releases prostacyclin and nitric oxide, which
prevents aggregation of platelets in normal tissue (targets platelet formation
at area of injury)
Medical relevance
 Aspirin
 Inhibits the formation of prostaglandins such as thromboxane A2
 At risk of bleeding out
o Inhibiting clot formation
 NSAIDs (non-steroidal anti-inflammatory drugs)
 Also ibuprofen and acetaminophen – not as big of a problem as aspirin
Blood clot formation

BIOL 4160 Exam 3