Based o n nelso ns case and the decision of having a

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Based o n Nelso n’s case and the decision of having a child, the results of the child acquiring at least one of the HbS allele for sickle cell is low. In the case that the father is heterozygous for sickle cell, the chances are distributed evenly with a 50% chance of inheriting the heterozygous genotype and the remaining demonstrating homozygosity for normal hemoglobin. In the case that Nelson reveals the homozygous genotype for normal hemoglobin, the child will indicate a 4:0 normal hemoglobin to heterozygous ratio. Combining the estimates with the fortunate case if Nelson acquires the homozygous genotype, the overall results demonstrate ¾ chance of the child inheriting complete homozygosity for normal hemoglobin and a ¼ chance of demonstrating as a carrier. Please be advised that these are only estimates and genetic testing is highly advised for each patient to reach a confirmed evaluation for available prevention and risks that are not included here. The process of this genetic screening involves a simple blood test that screens for hemoglobin S.
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  • Fall '19
  • Genetics, Sickle-cell disease, Heterozygote advantage

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