Dust bacteria fungi farmers lung is a

Dust
•
Bacteria,
•
Fungi,
•
Farmer’s
Lung (is a hypersensitivity pneumonitis induced by
the inhalation of biologic dusts coming from hay dust or mold
spores or other agricultural products.
•
Pigeon Breeder’s
Lung, caused the exposure to avian
proteins present in the dry dust of the droppings and
sometimes in the feathers of a variety of birds.

•
NON-Caseating Granulomas are the RULE
•
“Asteroid” bodies within these granulomas are virtually diagnostic,
but hard to find
•
Note: sarcoidosis is NOT limited to the lungs.

3. SMOKING RELATED
•
DIP ( D esquamative I nterstitial P neumonia)
because it looks like the alveolar wall
“epithelium” is peeling off into the alveolus
–
M>>F
–
CIGARETTES
–
100% Survival
Alveolar
Macrophages

4. PAP (Pulmonary Alveolar Proteinosis )
•
Very RARE, usually acquired
•
Proteinaceous Material in Alveoli
•
MINIMAL cellular inflammatory infiltrate
•
Like Pulmonary Edema, but MUCH Protein

2. Extrinsic disorders of restrictive lung diseases
•
Are extra-pulmonary diseases due to
•
Diseases of the chest wall,
•
Disease of the pleura,
•
Damage to the nerve
•
Damage to the respiratory muscles
•
They resulted in
•
lung restriction,
•
impaired ventilatory function
•
respiratory failure (eg, non-muscular diseases of
the chest wall, neuromuscular disorders
).

VASCULAR PULMONARY DISEASES
THREE TYPES
1. PULMONARY EMBOLISM (with or usually
WITHOUT infarction)
2. PULMONARY HYPERTENSION , leading to cor
pulmonale
3. HEMORRHAGIC SYNDROMES
–
GOODPASTURE SYNDROME
–
HEMOSIDEROSIS
, idiopathic
–
WEGENER GRANULOMATOSIS

Pulmonary Embolism
•
Usually secondary to debilitated states with
immobilization, or following surgery
•
Usually deep leg and deep pelvic veins (DVT),
NOT superficial veins
•
Follows Virchow’s triad, i.e., 1) flow problems, 2)
endothelial disruption, 3) hypercoagulabilty
•
Usually do NOT infarct, usually ventilate
•
When they DO infarct, the infarct is hemorrhagic
•
Decreased PO2, acute chest pain, V/Q MIS-match
•
DX: Chest CT, V/Q scan, angiogram
•
RX: short term heparin, then long term coumadin