Alzheimers Introduction Final.docx

Psychological symptoms of familial alzheimers disease

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psychological symptoms of Familial Alzheimer’s disease include behavioral psychological
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symptoms of dementia (BPSD) some of the symptoms are psychosis which are delusions, they also affective symptoms leading to anxiety and depression. AD could be prevented or treated by decreasing the production of Aβ and tau. In doing so there wouldn’t be aggregation in these proteins. Disease-modifying treatments are used to help treat Familial Alzheimer’s. “In the brain, neurons connect and communicate at synapses, where tiny bursts of chemicals called neurotransmitters carry information from one cell to another. Alzheimer's disrupts this process, and eventually destroys synapses and kills neurons, damaging the brain's communication network.” (3) These drugs interfere with amyloid β deposition this leads to toxic aggregation of Aβ . A phenothiazine which is used to treat psychotic disorders methylene blue is used in humans. The only problem with this drug is that it results in a lack of blinding which ultimately turns urine blue. Another Disease-modifying treatments is the modification of inflammation and oxidative damage Anti-inflammatory drugs such as Epidemiological protects the brain against the development of AD. It used in Familial Alzheimer’s by also treating cardiovascular disease by with lowering cholesterol. Another form of treatment is Cannabinoids by removing plaque forming proteins inside of brain cells. “Researchers found that high levels of amyloid beta were associated with cellular inflammation and higher rates of neuron death. They demonstrated that exposing the cells to THC reduced amyloid beta protein levels and eliminated the inflammatory response from the nerve cells caused by the protein, thereby allowing the nerve cells to survive.” (6) The effects of cannabinoids are being continuously studied and researched in science. Since not enough evidence has been found to fully support that cannabis use is an effective treatment for Alzheimer’s in humans, it remains difficult for the drug to be legalized. There are currently no
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clinical studies on cannabis treatment but the drug has been studied as an effective treatment for many other physiological processes. Cannabinoids have been proven to be effective in treatment and symptoms of Familial Alzheimer’s. Cannabinoids are made from Cannabis, delta-9-tetrahydrocannabinol. Cannabinoids are chemicals that lock onto molecules called cannabinoid receptors, these receptors then attach onto the surface of cancer cells. Endocannabinoids which are also molecules attach to the receptors going into the cell. “Brain cells have switches known as receptors that can be activated by endocannabinoids, a class of lipid molecules made by the body that are used for intercellular signaling in the brain. The psychoactive effects of marijuana are caused by THC, a molecule similar in activity to endocannabinoids that can activate the same receptors. Physical activity results in the production of endocannabinoids and some studies have
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  • Fall '15
  • Genetics, Alzheimer Disease, familial alzheimer

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