And passed from one generation to the next ie its

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(and passed from one generation to the next) (i.e. it’s responsible for heredity ) Ribonucleic Acid Transmits information from DNA to the ribosome (think copies of the original blueprints) Some special cases of RNA ( ribozymes ) can function like an enzyme Other important roles we may touch on in this course and that you’ll learn more about in future courses (its pretty neat stuff!) (DNA) (RNA) Nucleic acids are linear polymers of nucleotides . Function: To store, transmit and express hereditary (genetic) information. Made from C, H, O, N & P
Nucleic Acids Monomer units are called nucleotides Consists of a 5-carbon sugar, 1-3 phosphate groups and a nitrogenous base Let’s draw this out – it’ll help you remember. I won’t expect you to be able to draw the complete chemical structures but you will be required to recognize and name them. Drawing them out this will help!
Nucleic Acids Monomer units are called nucleotides Consists of a 5-carbon sugar , 1-3 phosphate groups and a nitrogenous base
Nucleic Acids Monomer units are called nucleotides Consists of a 5-carbon sugar, 1-3 phosphate groups and a nitrogenous base diphosphate triphosphate phosphate
Nucleic Acids Monomer units are called nucleotides Consists of a 5-carbon sugar, 1-3 phosphate groups and a nitrogenous base Helpful hint: Pur ines As in pure…like you want your silver to be. Silver = Ag Uracil is used in RNA instead of Thymine.
Nucleic Acids Monomer units are called nucleotides Consists of a 5-carbon sugar , 1-3 phosphate groups and a nitrogenous base
Naming Nucleotides P “d” if deoxyribose Nothing if just ribose nitrogenous base Number of phosphates M = mono D = di T= tri “P” is for phosphate!
Naming Nucleotides Practice Name this nucleotide: 1. dGMP 2. CTP 3. dCTP 4. ATP 5. dATP
Naming Nucleotides Practice Name this nucleotide: 1. dGMP 2. CTP 3. dCTP 4. ATP 5. dATP
Nucleotides Other Important Roles ATP GTP cAMP (cyclic AMP) NADH We’ll come back to some of these throughout the course. Keep an eye out!
HIV/AIDS The drug AZT is processed in the cell into AZT-ppp which mimics dTTP and inhibits a key viral enzyme . You know that whole structure/function thing…yeah…important! We’ll come back to discuss exactly how this how this inhibition works later in the course. dTTP
Ebola Brincidofovir is metabolized inside the cell to cidofovir disphosphate Looks like a C nucleotide! (without a sugar) Mimics C’s in the cell, which inhibits the virus (mechanism under investigation) Cidofovir diphosphate You know that whole structure/function thing…yeah…important! dCTP
Cancer Fluorouracil (5-FU) is a chemotherapy drug that inhibits an enzyme (thymidylate synthetase), thereby preventing production of dTTP.

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