Lecture_3-Neurotransmission_Review

Define an action potential describe where it occurs

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Define an “action potential”, describe where it occurs and how it is generated. Describe the movement of Na+ and K+ during the different phases of the action potential. Explain how an action potential travels down an axon and describe how certain anesthetic drugs exert their numbing effects. Describe the features of an axon that can influence the speed at which an action potential travels down an axon. Outline the major steps of neurotransmission and describe what would happen if you were to administer a drug that would stimulate and inhibit each of the steps.
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nucleus nucleus terminal Sensory Neurons Motor/Projection Neurons Major parts of a neuron
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Parts of a Neuron-Dendrites
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Dendritic spines: “spines”: protrusions from the dendrites where incoming neurons make contact
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Cell Body/Soma-Internal Anatomy • Nucleus: contains the DNA (genetic code) for the cell • Endoplasmic reticulum : folded membranes that are important for the synthesis of fats and proteins • Ribosomes : found on the endoplasmic reticulum and are involved in synthesizing proteins • Golgi complex : packages proteins into vesicles for transport • Microtubules : transport packaged proteins to other parts of the cell Mitochondria : provide energy for the cell; destroy toxins/drugs
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Transport of neuronal proteins down axon kinesin’s move vesicles along microtubules
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Varicosities at terminals Some neurons have multiple terminals that are studded with varicosities Varicosities are little protrusions containing vesicles of neurotransmitters Neurotransmitters can be released along the length of the terminals, as well as from the end (button) non- directional release a more wide-spread effect of the neurotransmitter
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Axon terminals and the “active zone”
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Define an action potential describe where it occurs and how...

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