100%(1)1 out of 1 people found this document helpful
This preview shows page 7 - 10 out of 19 pages.
Normally, the lymph nodes are composed of connective tissues that surround a fine mesh of reticular fibers and cells. In Hodgkin's lymphoma the normal structure of lymph nodes is destroyed by hyperplasia of monocytes and macrophages. The main diagnostic feature of Hodgkin's lymphoma is the presence of Reed-Sternberg cells in lymph node biopsy specimens.s/soenlargement of cervical, axillary, or inguinal lymph nodesomediastinal node second most common locationonodes are not painful unless they exert pressure on nervesoweight lossofatigueofeverochillsotachycardiaonight sweatsoA group of initial findings including fever (in excess of 100.4° F [38° C]), drenchingnight sweats, and weight loss (exceeding 10% in 6 months) are termed B symptoms and correlate with a worse prognosisoPain when drinking alcoholoSkin lesionsoAdvanced: hepatomegaly and splenomegaly, anemia7
Amanda SaccaCareostandard for chemotherapy is the ABVD regimen: doxorubicin (Adriamycin), bleomycin, vinblastine, and dacarbazineomore severeBEACOPP (bleomycin, etoposide, doxorubicin (Adriamycin), cyclophosphamide, vincristine (Oncovin), procarbazine, and prednisone)Non-Hodgkin’s Lymphomaheterogeneous group of malignant neoplasms of primarily B-, T-, or natural killer (NK) cell origin affecting all agesB-Cell lymphomasT cell and NKcell lymphomas pathoocause unknown; possible chromosomal translocations, environmental factors, immunodeficiency statesono hallmark feature like reed-sternberg cellsomimic leukemiaoDiffuse large B-cell lymphoma, the most common aggressive lymphoma, is a neoplasm that originates in the lymph nodes, usually in the neck or abdomen. oBurkitt's lymphoma is the most highly aggressive disease and is thought to originate from B-cell blasts in the lymph nodes.s/soNHLs can originate OUTSIDE the lymph nodesoMethod of spread unpredictableoPrimary clinical manifestation: painless lymph node enlargementoUsually disseminatedwhen diagnosedOther symptoms present depending where the disease has spreadoPatients with high-grade lymphomas may have lymphadenopathy and constitutional symptoms (B symptoms) such as fever, night sweats, and weight loss.Careochemo and radiationoWeird --- more aggressive lymphomas (diffuse large B cell) are more responsive to tx and more likely to be cured than indolent lymphomas that have naturally long course but are difficult to treat8
Amanda SaccaRituximab, a monoclonal antibody against the CD20 antigen on the surface of normal and malignant B cells, is used to treat NHL. Once bound to the cells, rituximab causes lysis and cell death. Numerous chemotherapy combinations have been used to try to overcome the resistant nature of this disease (Table 30-29). Complete remissions are uncommon, but the majority of patients respond with improvement in symptoms.