PathophysI_MDO_October1_2012_CaseDiscussion_Class (1)

Hypothalamic pituitary ovarian hpo axis evaluation

Info icon This preview shows pages 9–19. Sign up to view the full content.

View Full Document Right Arrow Icon
Hypothalamic-pituitary-ovarian (HPO) axis evaluation Ovaries: lack of/early loss of ovarian follicles; genetic abnormalities; toxins Anterior pituitary: prolactin-secreting adenoma; thyroid releasing hormone contributing to increased prolactin levels Hypothalamus: reduction in GnRH (eating disorders, extreme endurance activities)
Image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
http://www.accessmedicine.com/popup.aspx?aID=3155961
Image of page 10
Menorrhagia Definition: menstrual blood loss greater than 80 mL per cycle Contributing factors / pathophysiology Systemic disorders: pregnancy, ectopic pregnancy, miscarriage Uterine abnormalities: fibroids, endometrial polyps Bleeding abnormalities: vonWillebrand’s disease; idiopathic thrombocytopenic purpura Cirrhosis Clinical manifestations / course
Image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Anovulatory Bleeding Definition: dysfunctional or irregular uterine bleeding NOT related to an anatomic lesion of the uterus. 70% of cases are due to PCOS Etiology: immature HPO axis (no LH surge); declining ovarian function; hyperprolactinemia; high thyroid stimulating hormone (TSH); high FSH; hyperandrogenism Clinical manifestations / course
Image of page 12
PCOS Definition Hyperandrogenism and chronic anovulation in cases in which secondary causes have been excluded Presence of polycystic ovaries is a sign; is a nonspecific finding Etiology Selective insulin resistance
Image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
PCOS: Clinical Manifestations / Course Specific to PCOS Hirsutism, enlarged ovaries, infertility, amenorrhea, obesity, dysmenorrhea, persistent anovulation Chronic anovulation, obesity, hyperinsulinemia, and decreased sex hormone binding globulin all associated with endometrial cancer Insulin resistance and associated conditions
Image of page 14
Acanthosis Nigricans
Image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
http://www.accessmedicine.com/popup.aspx?aID=3157181
Image of page 16
http://www.accessmedicine.com/popup.aspx?aID=3157105
Image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
http://www.accessmedicine.com/popup.aspx?aID=3157066 PCOS - Pathophysiology
Image of page 18
Image of page 19
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern