Dai day after inoculation inoculation gene a training

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DAI = Day after inoculation Inoculation Gene a Training data : 127 genes with 20 data size ( 4 DAIs * 5 viruses )
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Gene expression inoculated by viruses in susceptible Arabidopsis thaliana plants only for 20 genes (1DAI and 2DAI) 1000 samples from my method 10000 samples from MCMCMC with Importance Sampling(ID)
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Gene expression inoculated by viruses in susceptible Arabidopsis thaliana plants 127 genes Genes with Higher connectivity Average global connectivity = 1.5847
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Gene expression inoculated by viruses in susceptible Arabidopsis thaliana plants 127 genes p-value check for transcription function - f is the number of genes with j th function in 127 genes. - m is the number of genes with j th function in 14 genes.
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Gene expression inoculated by viruses in susceptible Arabidopsis thaliana plants for 127 genes from my method (100 samples)
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Conclusion We need to select methodologies depending on the char acteristics of training data. To obtain the closest result to real networks, MCMCMC with I mportance and Order MCMC are suitable. MCMCMC with Importance Sampling has the best performance b ut it is slower than other MCMCs. Order MCMC has the second performance but it is four times fast er than MCMCMC with Importance Sampling. If we want to process large scale data and we do not have enou gh time to run MCMCs, Relevance Network and My method are proper. Also, several methods generate different networks so th at combining them will give better results.
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Conclusion Biological meaning Transcription genes have higher connectivities more t han other genes (from my method). That is, genes wit h transcription function may act as hubs in a network for response against viruses in Arabidopsis thaliana pl ant.
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  • Fall '19
  • MCMC, Bayesian network, Directed acyclic graph

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