cAMP inhibits phosphorylation of myosin and lowers intercellular concentrations

Camp inhibits phosphorylation of myosin and lowers

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cAMP inhibits phosphorylation of myosin and lowers intercellular concentrations of calcium” (Edmunds & Mayhew, p. 208, 2014), the end result is relaxation of smooth muscle. Airway resistance is decreased as a result of bronchodilation. Azelastine is an intranasal antihistamine. It comes in a spray (0.1%): 137 mcg per actuation or (0.15%): 205.5 mcg per actuation (Epocrates, 2019. Mrs. Jones will be started on the (0.1%): 137mcg per actuation dose. This start low and go-slow approach will provide her with relief but also leave room for additional dosing if required or if initial dosing amount does not alleviate symptoms. Follow-up discussing relief of symptoms will determine if Mrs. Jones requires a higher dose. “Antihistamines compete for histamine at the H1-receptor sites and are used to treat immunoglobulin (Ig) E-mediated allergy” (Edmunds & Mayhew, p.188, 2014). Antihistamines have drying effects; in Mrs. Jones case these effects would likely eliminate her runny nose which in turn would eliminate her itchy throat caused by the post nasal drip. Singulair (montelukast sodium), is a leukotriene receptor antagonist. Recommended doing for adults is 10mg orally once daily (Epocrates, 2019).
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  • Winter '19
  • Edmunds & Mayhew

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