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Lecture 9 - Recognition -Immune System-1

Each igg recognizes only 1 antigen each b cell

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Each IgG recognizes only 1 antigen Each B cell generates 1 type of Ig that recognizes 1 antigen HC and LC are different genes DNA for complete Ig arises from combinatorial joining of exons Regions at N terminus are most variable
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Immunoglobulin Fold
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Constant and Variable Domains
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V L and C L
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IgG Antigen Recognition at Loops
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MHC proteins present peptides of foreign proteins for T Cell Receptors on T cells
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MHC class 1 and 2 Recognition motif is 2 helices + 2 antiparallel sheets Recognition motif connected to TM domain by sandwich IgG-like domains and MHC class 1 is monomeric MHC class 2 is dimeric
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