In the absence of antiviral drug treatment the

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86) In the absence of antiviral drug treatment, the fitness of the least fit genotype is: A) 50 B) 100 C) 200 D) 400 E) 800 87) In the presence of antiviral drug (anti-V[B]) , the relative fitness of the least fit genotype is: 88) In the presence of antiviral drug (anti-V[A]) , the relative fitness of the least fit genotype is: 89) If the initial virus genepool was 100% Wt and all people were treated with anti-V[A] : 90) Assume that viral resistance was produced by a protective viral gene product (protein) that circulated in the blood stream and protected all viruses in the body , no matter what their genotype. In a person treated with antiviral drug anti-V[B] who was triple-infected with all three virus genotypes, the genotype producing the best “gene transport machine” would be: A) Wt B) A resist C) B resist D) A resist and B resist E) None of these answers is correct
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Use the following information for the next 5 questions (until you see a solid line): Suppose that Jane Schmoe was trying to develop a vaccine against HIV-AIDS. She infected a cell line originally derived from green monkeys with human HIV virus and then collected the progeny virus and used these to infect naïve green monkey cells taken anew from the green monkey cell culture line. After 20 iterations of this process (i.e., 20 cell line “passages”) she infected human CD4 + Helper-T cells and found that the evolved vaccine virus could no longer integrate its chromosomes into the Helper-T-cells’ chromosomes. After 20 more passages through the green monkey cell line, she found that the vaccine virus could no longer reverse-transcribe its chromosomes, and additional experiments showed that if the reverse-transcription defect was corrected the virus could not integrate its chromosomes into the CD4+ Helper-T-cells’ chromosomes. 91) If you examined human Helper-T cells infected with the “20 passages” vaccine virus, you would NEVER find
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