Sulfonamides Cont Bacteriostatic Action block para aminobenzoic acid to prevent

Sulfonamides cont bacteriostatic action block para

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Sulfonamides Cont. Bacteriostatic Action- block para -aminobenzoic acid to prevent the synthesis of folic acid in susceptible bacteria Indications- Treatment of infections caused by gram-negative and gram-positive bacteria
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Sulfonamides Cont. Sulfonamides Cont. Pharmacokinetics Well absorbed from the GI tract Metabolized in the liver, excreted in the urine and are teratogenic
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Sulfonamides (cont.) Sulfonamides (cont.) Contraindications- Known allergy to any sulfonamide, thiazide diuretics and pregnancy Adverse Effects- GI symptoms; Renal effects related to the filtration of the drug Drug-to-Drug Interactions- tolbutamide, tolazamide, glyburide, glipizide, or chlorpropamide and cyclosporine
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Nursing Considerations for Patients Receiving Sulfonamides Nursing Considerations for Patients Receiving Sulfonamides Assessment: Known allergy to any sulfonamide, sulfonylureas, or thiazide diuretics Physical status Skin and mucous membranes for any rash or lesions Specimens for culture and sensitivity tests Respiratory status Orientation, affect, and reflexes
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Nursing Considerations for Patients Receiving Sulfonamides Cont. Nursing Considerations for Patients Receiving Sulfonamides Cont. Abdomen Renal function tests Complete blood count
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Prototype Summary: Cotrimoxazole Prototype Summary: Cotrimoxazole
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Tetracyclines Tetracyclines Developed as semisynthetic antibiotics based on the structure of a common soil mold Most common medications- Tetracycline ( generic ) demeclocycline ( generic ) doxycycline ( Doryx, Vibromycin ) minocycline ( Arestin, Minocin )
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Tetracyclines Tetracyclines Bacteriostatic Action- Inhibits protein synthesis in susceptible bacteria, preventing cell replication Indications- Treatment of various infections caused by susceptible strains of bacteria; acne when penicillin is contraindicated for eradication of susceptible organisms and when penicillin is contraindicated
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Tetracyclines (cont.) Tetracyclines (cont.) Pharmacokinetics Adequately absorbed from the GI tract Concentrated in the liver, excreted unchanged in the urine Cross the placenta and pass into breast milk Contraindications- Known allergy to tetracyclines or to tartrazine, pregnancy, lactation and renal and hepatic dysfunction, Penicillin G, oral contraceptive therapy, methoxyflurane, digoxin
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Tetracyclines (cont.) Tetracyclines (cont.) Adverse Effects- Most GI, but possible damage to the teeth and bones.
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