192 193 recurrent gross hematuria is seen in pgidec

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192
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193
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RECURRENT GROSS HEMATURIA IS SEEN IN -(PGIDEC 2K) A) ALPORTS’S SYNDROME B) IGA NEPHROPATHY C) FOCAL SEG. GN D) DM ANS. IS ‘B’ I.E., IGA NEPHROPATHY [REF: HARRISON 18,H/EP. 2343] “IGA NEPHROPATHY IS A FREQUENT CAUSE OF RECURRENT GROSS OR MICROSCOPIC HEMATURIA”. “RECURRENT EPISODES OF PAINLESS GROSS HEMATURIA REPRESENT THE CLASSICAL CLINICAL PRESENTATION OF IGA NEPHROPATHY 194
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IMPORTANT CAUSES OF RECURRENT GROSS HEMATURIA 1) IGA NEPHROPATHY 2) ALPORTS SYNDROME 3) THIN GLOMERULAR BASEMENT MEMBRANE DISEASE 4) HYPERCALCIURIA 5) UROLITHIASIS ALSO KNOW IGA NEPHROPATHY IS THE MOST FREQUENT GLOMERULAR DISEASE IN THE WORLD. 195
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A FEATURE OF RENAL VASCULITIS IN CHILDREN IS - A) IGA RAISED (AIIMS SEPT 96) B) ANTINUCLEAR ANTIBODY IN SERUM C) LOW COMPLEMENT LEVEL D) CYTOPLASMIC ANTINUCLEAR AB IN SERUM 196
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H.S.PURPURA H.S. PURPURA IS THE MOST COMMON RENAL VASCULITIS AFFECTING CHILDREN. IT IS A VASCULITIS AFFECTING SMALL VESSELS CHARACTERIZED BY IGA DEPOSITION WITHIN VESSEL WALLS. IN KIDNEY THE DEPOSITION IS PARTICULARLY SEEN IN THE MESANGIAL REGION. SERUM IGA IS ALSO ELEVATED IN ABOUT 60% PATIENTS. EVEN THOUGH THE IMMUNE COMPLEXES CONTAINING IGA ARE ESSENTIAL TO THE PATHOPHYSIOLOGY OF H.S. PURPURA, SERUM COMPLEMENT LEVELS ARE USUALLY NORMAL . 197
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ANTINEUTROPHIL CYTOPLASMIC ANTIBODY LEVELS ARE NORMAL. HISTOLOGICAL EXAMINATION OF KIDNEY :- ON RENAL BIOPSY THE LESIONS MAY VARY FROM MILD FOCAL MESANGIAL PROLIFERATION TO DIFFUSE MESANGIAL PROLIFERATION TO CRESCENTIC GLOMERULONEPHRITIS. IT SHOULD BE STRESSED THAT WHATEVER MAY BE THE HISTOLOGIC LESION THE PROMINENT FEATURE ON IMMUNO FLORESCENCE IS DEPOSITION OF IGA WITHIN THE VESSEL WALLS OF MESANGIUM. 198
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199
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LABORATORY MANIFESTATIONS OF H.S.P:- ELEVATED SERUM IGA NORMAL COMPLEMENT NEGATIVE CRYOGLOBULIN ANCA NEGATIVE 200
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A FEATURE OF RENAL VASCULITIS IN CHILDREN IS - A) IGA RAISED (AIIMS SEPT 96) B) ANTINUCLEAR ANTIBODY IN SERUM C) LOW COMPLEMENT LEVEL D) CYTOPLASMIC ANTINUCLEAR AB IN SERUM ANS. IS ‘A’ I.E., IGA IS RAISED [REF: HARRISON 18'VE P. 2797] H.S. PURPURA IS THE MOST COMMON RENAL VASCULITIS AFFECTING CHILDREN. 201
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ADULT POLYCYSTIC KIDNEY IS INHERITED AS – (AI 97) A) AUTOSOMAL-CO-DOMINANT B) AUTOSOMAL DOMINANT C) AUTOSOMAL RECESSIVE D) X-LINKED DOMINANT 202
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ADULT POLYCYSTIC KIDNEY DISEASE ADULT POLYCYSTIC KIDNEY DISEASE IS INHERITED AS AUTOSOMAL DOMINANT TRAIT. MOST PEOPLE WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE LIVE FOR DECADES WITHOUT DEVELOPING SYMPTOMS. THE PATIENT USUALLY PRESENTS IN 3RD TO 4TH DECADE, FOR THIS REASON AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY IS OFTEN CALLED ADULT POLYCYSTIC KIDNEY DISEASE 203
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NOTE THAT POLYCYSTIC KIDNEY DISEASE (NOT ADULT POLYCYSTIC KIDNEY DISEASE) CAN BE INHERITED IN TWO FORMS.
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