4½ marks iv state the effect of e on plasma glucose

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(4½ marks) (iv) State the effect of E on plasma glucose level. Suggest two possible ways in which E might have produced this effect. (2½ marks) (b) In order to study how E produces its effect, a further investigation was carried out where drug S, which can destroy the pancreatic β cells, was used. Four groups of normal rats with the same plasma glucose level were treated as follows Group A: not treated with either E or S Group C: treated with S first and then E Group B: treated with S only Group D: treated with E only Figure 2 shows the plasma glucose levels of the rats at the end of the experiment. Deduce how E produces its effect based on the results shown in Figure 2. (4 marks) (c) Suggest one possible medical application of E. (1mark)
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18 Homeostasis Last update: 2019-12-24 - 17 - AL030201c (modified) The following diagram is a model illustrating the structure of a cell membrane: In human body, insulin exerts its influence on cellular metabolism by binding to receptors located at the cell membrane of target cells. Z is an insulin receptor. (a) Give TWO types of cells where Z can be found in abundance. (2) (b) State ONE biochemical process that is activated inside the target cell when insulin is attached to Z. (1) (c) It is known that an obese person has a higher risk of developing diabetes. This is because a chemical released from the fat tissue inhibits the binding of insulin to Z. Suggest and explain the effect of this inhibitor on blood glucose level. (3)
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18 Homeostasis Last update: 2019-12-24 - 18 - AL040110 The graph below shows the effects of different hormonal treatments on the blood glucose level of five groups of healthy rats. The same dose of each hormone was given to the different groups. Hormone C is a stress hormone. (a) Explain with one reason whether food should be provided to the rats during the 8 hours before the hormonal treatment. (2 marks) (b) With reference to the trends shown in the graph, compare and contrast the effect of adrenaline on blood glucose level with that of glucagon. (4 marks) (c) Calculate the change in blood glucose level for group 4 and group 5 rats five hours after the hormonal treatments. Put your answer in the table below: (2 marks) (d) Compare the effect brought about by the hormonal treatment in group 4 and group 5 with the sum of the effects brought about by the respective individual hormonal treatments, what conclusion(s) can you draw? Support your answer using the data from the above table. (3 marks) (e) It is known that diabetics have a slightly higher glucagon level in their blood than normal people. According to the findings of the above experiment, why is it that diabetics have to avoid emotional disturbance? (3 marks)
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18 Homeostasis Last update: 2019-12-24 - 19 - AL060110 In a medical test, three adults, A, B and C, were each asked to drink a solution containing 100g of glucose after they had fasted for 12 hours. Their plasma glucose level and insulin level were determined before glucose intake, and these levels were also monitored at regular intervals for the subsequent 4 hours. The results are shown in Figure 1 and Figure 2 below. A is the only healthy
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  • Fall '19
  • Blood sugar

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