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Fyn signals via adapter molecules shc grb2msos to h

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and the inhibitory action of caveolin-1 is relieved. Fyn signals, via adapter molecules (Shc, Grb2/mSOS), to H-Ras. The activation of H-Ras (in rafts or caveolae) eventually leads to the activation of MAP kinases and signaling to the cell nucleus. K-Ras (light yellow) is present in a different membrane compartment from caveolins due to a polybasic region (pink) and takes part in different signaling events. Raft and caveola membranes are indicated in green. Small vertical lines within the noncaveolar membranes indicate cholesterol concentration. Fyn, mSOS, and Ras associate with the plasma membrane via lipid modifications (black dots). Right of dashed line: Cholesterol depletion of the membrane leads to the loss of the caveolin coat from the membrane. Concomitantly caveolae and functional rafts disappear. This prohibits the local enrichment of H-Ras, Src kinases, adapters, and uPAR. Thus, signaling via caveolin is abolished. Experimental Cell Research 261, 111–118 (2000) Martin Stahlhut, Kirsten Sandvig and Bo van Deurs
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Rob Parton: Science 293 2404 (2001)
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Caveolae pictures 100 nm.
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Fyn signals via adapter molecules Shc Grb2mSOS to H Ras The...

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