Evaluation prevention orrelief ofbronchospasm

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EvaluationPreventionorreliefofbronchospasm.● Increase in ease of breathing. ● Prevention of bronchospasm orreduction of frequency of acuteasthma attacks in patients withchronicasthma.● Prevention of exercise-inducedasthma. ● Reversal of signs andsymptomsofanaphylaxis.● Increase in cardiac rate andoutput, when used in cardiacresuscitation.● Increase in BP, when used as avasopressor.● Localization of local anesthetic. ● Decrease in sinus and nasalcongestion.BRAND NAME: GENERIC NAME: VASOPRESSINCLASSIFICATION: ANTIDIURETICHORMONERECOMMENDEDDOSAGE,ROUTE, AND FREQUENCY:Diabetes insipidus IM, Subcut (Adults):5– 10 units 2–4 times daily. IM, Subcut (Children):2.5– 10 units 2– 4 times daily. IV(Adults and Children):0.0005units/kg/hr, double dosage q 30 minas needed to a maximum of 0.01units/kg/hr. Pulseless VT/VF, Asystole, or PEA(ACLS guidelines)IV (Adults):40 units as a singledose (unlabeled). IV (Children):0.4 units/kg afterresuscitation and at least 2 doses ofepinephrine. Vasodilatory shock IV (Adults):0.01– 0.1 units/min,titrate to effect. IV (Infants and Children):0.0003–0.002 units/kg/min, titrate to effect. GI Hemorrhage IV (Adults):0.2– 0.4 units/min thentitrate to maximum dose of 0.9units/min; if bleeding stops continuesame dose for 12 hr then taper offover 24– 48 hr. IV(Children):0.002–0.005units/kg/min then titrate to maximumdose of 0.01 units/kg/min; if bleedingstops continue same dose for 12 hrthen taper off over 24– 48 hr.DRUGACTION:Altersthepermeability of the renal collectingducts, allowing reabsorption of water.Directly stimulates musculature of GItract. In high doses acts as anonadrenergicperipheralvasoconstrictor.TherapeuticEffects: Decreased urine output andincreased urine osmolality indiabetes insipidus.Absorption:IM absorption may beunpredictable. Distribution:Widelydistributed throughout extracellularfluid.Metabolism and Excretion:Rapidlydegraded by the liver and kidneys;5% excreted unchanged by thekidneys.Half-life:10–20min.TIME/ACTIONPROFILE(antidiuretic effect)Page | 243
ROUTE ONSET PEAKDURATION IM, subcut unknown unknown 2–8 hr IV unknownunknown 30–60minDRUG-DRUG AND DRUG-FOODINTERACTIONS:Drug-Drug:Antidiuretic effect maybepby concurrent administration ofalcohol, lithium, demeclocycline,heparin,ornorepinephrine.Antidiuretic effect may be q byconcurrentadministrationofcarbamazepine,chlorpropamide,clofibrate, tricyclic antidepressants,orfludrocortisone.Vasopressoreffectmaybeqbyconcurrentadministration of ganglionic blockingagents.INDICATIONS:Central diabetesinsipidus due to deficient antidiuretichormone.UnlabeledUse:Management of pulseless VT/VFunresponsive to initial shocks,asystole, or pulseless electricalactivity (PEA) (ACLS guidlines).Vasodilatory shock. Gastrointestinalhemorrhage.

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Term
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Low molecular weight heparin

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