A a b c d b a c d b c a d c b d c b a d e c d a b 35

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Biology
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Chapter 19 / Exercise 3
Biology
Martin/Solomon
Expert Verified
(A) A-B-C-D (B) A-C-D-B (C) A-D-C-B (D) C-B-A-D (E) C-D-A-B 35. ln a family study following an autosomal dominant trait through three generations, two loci are compared for their potential linkage to the disease locus. In the following three- generation pedigree, shaded symbols indicate the presence of the disease phenotype, and the expression of ABO blood type and MN alleles are shown beneath each individual symbol. Which of the following conclusions can b e made about the linkage of the disease allele, ABO blood group locus, and MN locus? (A) The ABO and MN alleles are linked, but assort independently from the disease allele (B) The ABO, M, and disease alleles all assort independently
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Biology
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Chapter 19 / Exercise 3
Biology
Martin/Solomon
Expert Verified
(C) The disease allele is linked to the ABO locus (D) The disease allele is linked to the ABO and M loci (E) The disease allele is linked to the MN locus 36. The map distances between four syntenic loci are shown below: What is the chance of recombination between loci A and D? (A) 0.04 (B) 0.06 (C) 0.08 (D) 0.10 (E) 0.14 37. The pedigree below shows a family in which hemophilia A, an X-linked disorder, is segregating. PCR products for each member of the family are also shown for a short tandem repeat polymorphism located within an intron of the factor VIII gene. What is the best explanation for the phenotype of individual II-1 ? (A) Heterozygous for the disease-producing allele (B) Homozygous for the disease-producing allele (C) Homozygous for the normal allele (D) Incomplete penetrance (E) Manifesting heterozygote 38. The pedigree below represents a family in which phenylketonuria (PKU), an autosomal
recessive disease, is segregating. Southern blots for each family member are also shown for an RFLP that maps 10 million bp upstream from the phenylalanine hydroxylase gene. What is the most likely explanation for the phenotype of II-3? (A) A large percentage of her cells have the paternal X chromosome carrying the PKU allele active (B) Heteroplasmy (C) Male I-2 is not the biological father (D) PKU shows incomplete penetrance (E) Recombination has occurred 39. Two phenotypically normal second cousins marry and would like to have a child. They are aware that one ancestor (great-grandfather) had PKU and are concerned about having an affected offspring. They request ASO testing and get the following results. What is the probability that their child will be affected? (A) 1.0 (B) 0.75 (C) 0.67 (D) 0.50 (E) 0.25 40. A 66-year-old man (I-2) has recently been diagnosed with Huntington disease, a late-onset,
autosomal dominant condition. His granddaughter (III-1) wishes to know whether she has inherited the disease-producing allele, but her 48-year-old father (II-1) does not wish to be tested or to have his status known. The grandfather, his unaffected wife, the granddaughter, and her mother (II-2) are tested for alleles of a marker closely linked to the huntingtin gene on 4p16.3. The pedigree and the results of testing are shown below. What is the best information that can be given to the granddaughter (III-1) about her risk for developing Huntington disease?

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