Hyperlipidemia: high risk for acute pancreatitis, diet weight loss, HMG CoA(statins).TX; reduce junk food, begin exercise, try niacin and fibrates if no success. Treat this before hypercholesteremia. Rhabdomyolysis: acute break down of skeletal muscle causing acute renal failure. Triad: red-brown urine, muscle pain, weakness. Labs CK,urine:proteinuria,BUN,creat,K,Cholesterol<200, HDL >40, LDL <100, Triglycerides <150 TX first line life modifications, niacin fenofibrateHeart disease leading cause of death in women.Kids with scoliosis=check hips as wellAtopic dermatitis=allergic response, flat macular patch excoriation, puritisAmenorrhea=16 year old fully developed, missing a periodAfrican American female thiazide and CCBOtitis media with effusion= no tx: pneumotypy with fluid bulging TM.Papular-vesicle rash starts on face=measles, flat red spots, corza, conjunctivitis, feverPeptic ulcer disease=Lichen planusAcne Rosea=TalwinHCTZ=Thiazides- largest studied drug, lowers potassium, increases gout, increase digoxin toxicityThiazide is beneficial for osteoporosis, reduces calcium excretion by kidneys, and stimulates osteoblasts which help with bone growth.Pts with serious sulfa allergies avoid thiazide. Thiazides: Contraindications: hypotension, gout, renal failure due to loss of sodium, hypokalemia, may worsen DM, lead to metabolic alkalosis, by action of the renin angiotensin system, decreased volume and arterial pressure. May cause hyperglycemia due to insulin resistance and decreased insulin release. Thiazide(HCTZ) used for uncomplicated HTN, heart failure, edema. Adverse Rx: HYPERGLYCEMIA, ELEVATED TRIGLYCERIDES AND lower HDL insulin insensitivity, ELEVATED URIC ACID CAN PRECIPATE A GOUT ATTACK, Hyperkalemia MUSCLE WEAKNESS, ARRYTHMIA).