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Lectures_6_and_7-phosphorylation

Mitogen activated protein kinases mapks activation of

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Mitogen-activated Protein Kinases (MAPKs) Activation of signaling begins with the stimulation of small G proteins ( Ras and Rac ) Involves a number of linker proteins that couple the small G potein (e.g. Ras) to the RTK Small G protein activation leads to a series of kinase P’lations (chain of P)
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Small G Proteins Large superfamily of G proteins that are smaller in molecular weight than the heterotrimeric G proteins Like , they bind guanine nucleotides, have GTPase activity and undergo a change in affinity for targets when GTP binds Molecular switches that control a variety of specific cell functions
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Small G Proteins Activity is regulated by: GEFs (guanine nucleotide exchange factors) increase activity) GAPs (GTPase-activating proteins) inhibit activity (like RGS) GIPs (GTPase-inhibiting proteins) increase activity and then inhibit (AGS3-like)
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