Interphasetime cell isnot dividing carryingout normal

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•Interphase–time cell isnot dividing; carryingout normal functionsand preparing to divide •Mitosis only 5-10% ofcell cycle Cell Cycle: Interphase •Centrioles and chromosomes replicate •Chromosomes–DNA wrapped aroundproteins and tightly packaged into individualunits –Uncoiled during interphase (chromatin granules) –Replicate so that each new daughter cell gets acopy of each chromosome 8/30/2016 4 DNA Replication •DNA strands “unzip”(involves enzyme DNAhelicase) •Complimentary base pairing–new nucleotides arematched to existing strands –Remember from Chapter 2: A pairs with T, C pairs withG! –Involves enzyme DNA polymerase •Results in two identical DNA molecules, eachcomposed of one ‘old’ strand and one ‘new’ strand
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DNAReplication 8/30/2016 5 Mitotic Phases •Prophase •Metaphase •Anaphase •Telophase *Note: remembering ‘PMAT’will help you remember theorder of the phases!
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Mitosis: Prophase •Replicated chromosomes coil and becomevisible –Each has two chromatids (two copies) joined by acentromere •Nuclear envelope breaks down
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