oral or nasal ulcers arthritis serositis kidney disease and brain disease

Oral or nasal ulcers arthritis serositis kidney

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oral or nasal ulcers, arthritis, serositis, kidney disease, and brain disease (Askanase, Shum & Mitnick, 2012). Whereas, Psoriasis is a chronic, relapsing, proliferative, inflammatory disorder that involves the skin, scalp, and nails and can occur at any age affecting 1 – 4% of the population (Huether & McCance, 2012, p.1049). It is characterized by both the dermis and epidermis becoming thickened with cellular hyperproliferation, altered keratinocyte differentiation, expanded dermal vasculature, infiltration of neutrophils and lymphocytes, and inflammation (Huether & McCance, 2012, p. 1049). The disease can be mild-moderate to severe with various types of psoriasis existing including plaque, inverse, guttate, pustular, and erythrodermic (Huether & McCance, 2012 p. 1049). Furthermore, Psoriatic arthritis of hands, feet, knees, and ankle joints develops in 5% of 30% of cases comorbidities associated with psoriasis (Huether & McCance, 2012, p. 1050). Treatment requires the maintaining of skin moisture, reducing epidermal cell turnover and pruritus, and ensuring immunomodulation (Huether, & McCance, 2012, p. 1050). Genetic SimilaritiesSLE is noted to have a strong genetic component and familial aggregation with a familial prevalence of 5.6% if one first degree relative is affected, 2-5% dizygotic twins, and 29-57% monozygotic twins (Askanase, Shum, & Mitnick, 2012). Just as SLE has familial and genetic predispositions so too does Psoriasis. According to with Huether & McCance (2012) familial history is established and the genetic mechanisms are complex. ReferencesAskanase, A., Shum, K., & Mitnick, H. (2012). Systemic Lupus Erythematosus: An Overview. Social Work In Health Care, 51(7), 576-586. doi:10.1080/00981389.2012.683369
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Huether, S. E., & McCance, K. L. (2012). Understanding pathophysiology (5th ed.). St. Louis, MO: Mosby.
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