standard dose average effective dose d Agonist vs Antagonist Agonist Activate

Standard dose average effective dose d agonist vs

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(standard dose), average effective dose d. Agonist vs. Antagonist Agonist : Activate receptors, mimic the body's own enzymes/hormones etc., have affinity and high intrinsic activity Antagonist: Prevent receptor activation, block action of the body's own enzymes/hormones etc., has affinity but no intrinsic activity, produce their pharmacologic effects by preventing the activation of receptors by agonists non-competitive antagonists bind irreversibly to receptors competitive antagonists bind reversibly to receptors Partial agonist: may act as either agonist or antagonist. (Usually have innately agonistic effects, but can also be used to bind to receptor sites at a higher affinity than more potent agonists, having an antagonistic effect.), maximal effect that a partial agonist can produce is lower than that of a full agonist because a partial agonist only has moderate intrinsic activity e. Loading doses Higher dose given initially to get to plateau faster. Maximal Efficacy : The maximal response a drug can produce. How well the drug does its job. (The drug which can produce a greater effect is more effective.), indicated by the height of the dose response curve Relative Potency: The amount of drug needed to elicit an effect. (A drug that requires less to have the same effect is more potent.), position of the dose response curve along the x axis, potency is not an important quality of a drug (45) * Efficacy and potency are completely independent qualities f. Drug half-life and application Amount of time for half of the drug in the system to be removed. Drugs doses are given until a plateau is reached. (usually about 4 doses). It takes the same amount of half lives for the drug to be removed from the system (usually about 4)
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