gradually reduced because of the failure to follow protocols and the inability

Gradually reduced because of the failure to follow

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gradually reduced because of the failure to follow protocols and the inability to produce consistent results. However, the idea of using bacteria to fight cancer was still in effect.
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Harvey 2 According to the Journal of Cancer Metastasis and Treatment, in 1959, a clinical trial performed extensive research that led to the discovery of the tumor necrosis factor in 1975 (“Cancer Immunotherapy: a Brief Review of the History, Possibilities, and Challenges Ahead”). Even though antitumor responses were seen, it was difficult to infect most patients with illnesses to reach the tumor necrosis factor. Also, when infection occurred, it was difficult to control its severity. This meant that patients were risking their current health state for a possibly worse one in the future, or even death. The immune system also plays a role in treating cancer. The idea that the immune system was capable of detecting and killing cancer cells was developed by scientists Brunet and Thomas. This concept was not accepted immediately but now plays a large role in the success of immunotherapy. The immune system has special T-Cells that target invading viruses or unwanted bacteria. So, the viruses are able to identify cancerous cells by invading them. Healthy cells have the ability to fight off viruses, whereas cancer cells do not. Consequently, when the virus infects a cancer cell, it will make copies until the cell is recognized by the immune system. According to the National Cancer Institute, “The dying cancer cell releases materials, such as tumor antigens, that allow the cancer to be recognized, or “seen,” by the immune system” (NCI). These viruses -or Oncolytic viruses- alert the immune system that something is wrong. Then, the immune
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  • Fall '11
  • Rostein

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