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Lecture 32 - Endocrine Physiology I

Most hydrophobic steroids are bound to the plasma

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Most hydrophobic steroids are bound to the plasma protein carriers Only unbound hormones can diffuse into the target cell Steroid hormone receptors are in the cytoplasm of the nucleus Some steroid hormones also bind to membrane receptors that use second messenger  systems to create rapid cellular responses The receptor-hormone complex binds to DNA and actives or prepressed one or more  genes Activated genes create nre mRNA that moves back to the cytoplasm Translation produces new proteins for cell processes Amine Hormones Synthesis and storage Derived from AAs Most from tyrosine Catecholamines  Dopamine, NE, E
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Thyriod hormoes T3 and T4 Hypothalamus and Pituitary Pituitary sits in a bony receptacle Extension of the hypothalamus Anterior and posterior lobe Posterior Lobe True extension of the hypothalamus Generates two main hormone ADH and oxytocin 9AA  preprohormones are synthesized by special nuclei in the hypothalamus send their axons down where they terminate in the capillary bed in the posterior pituitary cleavage produces ADH and ocytocin as well as a carrier all are transported in vesicles doen the axons of the neurons in which they are  synthesized to the PP stored in vesicles in nerve endings in the PP when heurn is depolarized, an AP arrives at nerve ending Ca influx, exocytosis,  hormone released into capillary network ADH secreted under condutions when you want water retained for hemostasis Secreted in response to osmolarity, hypovolemia, hyeperosmolarity Increases permeability of tubules will accomplish increased water retention
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Most hydrophobic steroids are bound to the plasma protein...

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