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PHRM 514 STD's Fall 2012 (1)

Mehring pm sexually transmitted diseases in porth cm

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Unformatted text preview: Mehring, PM. Sexually transmitted diseases. In: Porth, CM, editor. Pathophysiology Concepts of Altered Health States. 7th Ed. Philadelphia: Porth Lippincott Williams and Wilkins; 2005:1101-1110. Congenital Syphilis n T. pallidum can cross the placenta anytime during pregnancy n May result in: § Death § Prematurity § Congenital syphilis n Symptoms may be seen in: § 1st months of life § Later in childhood or adolescence Knodel, LC. Sexually transmitted diseases. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:2011-2028. Syphilis: Diagnosis n Microscopic examination from specimens collected from lesions or enlarged lymph nodes with identification of: § T. pallidum spirochete § Antibodies to T. pallidum n Serologic testing § Nontreponemal § Treponemal Knodel, LC. Sexually transmitted diseases. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:2011-2028. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines. MMWR 2010;59(RR-12):1-116. Darkfield Micrograph of Treponema Pallidum Treponema pallidum. Centers for Disease Control and Prevention. http://www.cdc.gov/std/syphilis/images/treponema-pallidum.htm. Updated August 2, 2012. Accessed October 17, 2012. Syphilis Diagnosis n Nontreponemal § Venereal Disease Research Laboratory (VDRL), rapid plasma reagin (RPR) test § Positive indicates the presence of any stage of syphilis or congenital syphilis § May see false positives § Reported quantitatively – decline with treatment and may become nonreactive § Used for screening and for following progression of disease, recovery after therapy, and reinfection n Treponemal § Fluorescent treponemal antibody absorption (FTA- ABS), T. pallidum hemagglutination assay (TPHA) § More sensitive § Used for confirming diagnosis § Not used for following treatment § Remain reactive for life in most patients Knodel, LC. Sexually transmitted diseases. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:2011-2028. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines. MMWR 2010;59(RR-12):1-116. Herpes Simplex Virus (HSV) Herpes Simplex Virus Statistics n Estimated seroprevalence of HSV2 in those age 14 to 49 years from 2005 to 2008 = 16.2% n Overall decrease in prevalence n 306,000 office visits in 2009 Centers for Disease Control and Prevention. Centers for Disease Control and Prevention....
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