P proteins on tyrosine residues less than 1 dual

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P proteins on tyrosine residues (less than 1%) “dual-function” kinases can P all 3 In all cases, the kinases transfer the terminal P from ATP to the hydroxyl moiety of the given amino acid Requires Mg2+ P’lation changes the charge of the protein substrate alters conformation alters function
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Schema of phosphorylation
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Ser-Thr Kinases The most well-investigated protein kinases in the brain are those stimulated by cAMP, cGMP, Ca2+ and DAG
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