Malaise fatigue facial edema hepatitis angioedema

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malaise, fatigue, facial edema, hepatitis, angioedema), skin reaction Steven-Johnson Syndrom, toxic epidermal necrolysis, liver failure. Chapter 97: pg. 1183Anthelmintics (Helminths are parasite worms and anthelminths are drugs against them)A.Recognize the main therapies for helminthiasis. Also, identify when drug therapy is definitely indicated, as well as factors that may preclude drug therapy.Treatment for helminthiasis is not always indicated as most of the parasites (nematoda, cestode, trematoda) do not reproduce in the human body. In the absence of reinfestation, they simply subside and as adult worms die. Treatment is option. In countries where providers and medication is available, drug therapy is definitely indicated. But in less fortunate areas, preventive measures help by improving hygieneand elimination carriers. a.Mebendazole (Vermox): i.Used for intestinal roundworms (nematoda). It clears infestation with pinworms, hookworms, and giant roundwormsii.MOA: prevents uptake of glucose by susceptible worms and glucose deprivation results in slow death. b.Albendazole (Albenza):i.Used against many cestode (tapeworm), and nematode (roundworm) parasites including for larva of toenia solium and echinoccous granulosis.Albendazole is a drug of choice for infestation of hookworm, pinworm, whimpworms, giantround worm, pork roundworm, Chinese liver flukeii.MOA: inhibits polymerization of tubulin and prevents cytoplasmic microtubules and as a result uptake of glucose is prevented. iii.ADR: mild-moderate liver impairment, bone marrow suppression so it cancause agranulocytosis, granulocytopenia, should not be used pregnant teratogenic. c.Pyrantel pammoate (Pin-X)i.Used against intestinal nematodes, pinworms and hookworms. Alternative to mebendazole, albendazole.ii.MOA: depolarizes neuromuscular blocking agent that causes spastic paralysis of intestinal parasites that are cleared in feces.iii.ADV: GI; n/v, diarrhea, stomach pain, dizziness, drowsinessd.Ivermectin (Stromectol) :i.Used against many nematodes; ochocerciasis, intestinal strongyloidias, also used to mites and lice.
ii.MOA: disrupts nerve traffic and muscle function of parasite by opening chloride ion on cell surface and rush into nerve/muscle cells, then hyperpolarization causes cells paralysis, death.iii.ADR:Mazotti reaction: pruritic, rash, fever, lymphnode tenderness in treating onchoceriasis (river blindness)Antiprotozoal DrugsA.Understand chloroquine treatment vs chloroquine resistant treatment options. And the difference in administration timing and durations.a.Selection of antimalaria drug is based on two factors: the goal of treatment and drug resistance that cause strain of plasmodium (protozoa of genus that cause malaria). Drugs of choice is based on treatment and prophylaxis. b.Chloroquine is a drug of choice for mild to moderate malaria therapy acute attack by chloroquine sensitive strains of p.falcipoarum or p.vivax. A 3 day dourse of treatment produces clinical cure. c.For the strains of P.falciparum or P.vivax that are resistance to chloroquine

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