Leah is lazy homozygous for the h allele the h locus

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H allele). Leah is lazy (homozygous for the h allele). The H locus is linked to a chromosomal marker, which exists in two forms Ω+ or Ω-­. If no recombination occurs, which of the following genotypes could be present in one of Bob and Leah's grandchildren? A. hhΩ+Ω+ B. HHΩ-­Ω-­ C. hhΩ-­Ω-­ D. hhΩ+Ω E. HhΩ+Ω-­ 32&33 THIS PROBLEM IS WORTH 2 POINTS – FILL IN BOTH NUMBERS ON YOUR SCANTRON ______ results in two ______ daughter cells;; while ____ results in four _____ daughter cells. A. Mitosis, haploid;; meiosis, diploid B. Meiosis, haploid;; mitosis, diploid C. Mitosis, diploid;; meiosis, haploid D. Meiosis, diploid;; mitosis, haploid 34&35 THIS PROBLEM IS WORTH 2 POINTS – FILL IN BOTH NUMBERS ON YOUR SCANTRON In a population of rare white frogs, you find a single mutation in the ebony gene that affects skin color. When you cross homozygous ebn mutants (again, wild type is white), you find the results shown below (i.e. the offspring of frogs homozygous mutant for ebn are either dark or white.) No other genes are mutant in these animals. This must be the result of A. An allelic series B. A pleiotropic mutation C. Multiple alleles D. Recessive epistasis E. Variable penetrance 36&37 In Bushwa trees, the locus for leaf colour has three alleles: R (red), G (green), and B (brown). R is dominant to both G and B , G is dominant to B . In the progeny of the cross BR x BG , what fraction will be brown ? A. All B. ¾ C. ½ D. ¼ E. 0
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Page 7 38&39 Next two questions: The mutation that causes sickle cell disease (SCD) creates a restriction fragment length polymorphism (RFLP) in the human HBB locus. Specifically, the mutation destroys a Dde I site at codons 5-6. Three samples, one from an SCD patient, one from an SCD carrier, and one from a normal individual, were digested with Dde I and run on the above gel. THIS PROBLEM IS WORTH 2 POINTS – FILL IN BOTH NUMBERS ON YOUR SCANTRON What type of gel and analysis were used to detect these bands? A. DNA gel, Southern blot procedure B. Protein gel, separation based on charge C. DNA gel, separation based on charge D. Protein gel, Southern blot procedure E. Protein gel, antibody used as molecular probe 40&41 THIS PROBLEM IS WORTH 2 POINTS – FILL IN BOTH NUMBERS ON YOUR SCANTRON What can we say about the samples in lanes 1 and 2? A. Patient, carrier B. Patient, Normal C. Carrier, Patient D. Carrier, Normal E. Normal, Carrier 42&43 THIS PROBLEM IS WORTH 2 POINTS – FILL IN BOTH NUMBERS ON YOUR SCANTRON Fill in the blanks. A gene that encodes a protein required for the repair of certain types of DNA damage is likely to be a _______. A gene that encodes a protein required to relay a signal telling a non-­dividing cell to divide is likely to be a _______. A. oncogene;; tumor-­suppressor gene B. tumor-­suppressor gene;; oncogene C. oncogene;; oncogene D. tumor-­suppressor gene;; tumor-­suppressor gene E. malignant, hemizygous 44&45 THIS PROBLEM IS WORTH 2 POINTS – FILL IN BOTH NUMBERS ON YOUR SCANTRON One of the first widely successful genetically modified crops was a strain of soybeans that… A. That was trisomic for a soybean chromosome B.
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