a one quarter b one third c half d the same as e two times AUD Associated

A one quarter b one third c half d the same as e two

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of men. a) one-quarter b) one-third c) half d) the same as e) two times AUD Associated Problems Anxiety Depression AUD Associated Problems Antisocial Personality Disorder Conduct Disorder (in adolescence) Aggression Biological Factors Genetics of alcoholism Family Studies Twin Studies concordance rates MZ vs DZ twins Males: 56% vs 33%; Females: 30% vs 17% Adoption Studies
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Possible Genetic Mechanisms Personality Traits (e.g., sensation seeking, binge drinking?) Alcohol Metabolism Possible Genetic Mechanisms Neurochemical Mechanisms Endorphins (endogenous opioids) “natural pain relievers” Released during exercise, excitement, etc. Also released in response to alcohol Produce analgesia and a feeling of well being Involved in controlling pain, emotion, stress Endorphins disinhibit dopamine pathways ! reward pathways in the brain are activated Alcohol Release of endorphins Increased activity along dopamine (reward) pathways Endogenous Opioids Endorphins are similar to morphine: effects on pain produce tolerance & withdrawal symptoms in lab animals Some individuals may experience an exaggerated activation of the endogenous opioid system in response to alcohol. Endogenous Opioids Possible role in brain’s response to alcohol Opioid system response in people who seem predisposed to consume high levels of alcohol Effects of receptor antagonists on lab animals (reduction in self-administration of alcohol) Effects of Naltrexone, an antagonist of endogenous opioids, on alcoholic patients Naltrexone blocks the effects of endorphins and the effects of opiates, leading to a reduction in alcohol consumption Naltrexone is an antagonist of (blocks receptors for) endorphins and opiates Alcohol Release of endorphins Increased activity along dopamine (reward) pathways, due to disinhibition Naltrexone
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Question Which of the following statements about Naltrexone is/are true?
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