NUR 301 Spring 2018 Endocrine Pathologies (except DM) .doc

Adrenocortical hyperfunction glucocorticoid cushing

Info icon This preview shows pages 7–9. Sign up to view the full content.

Adrenocortical Hyperfunction - Glucocorticoid -Cushing Disease or Syndrome Cushing Syndrome - chronic hypercortisolism with/without primary involvement Cushing Disease - pituitary dependent hypercortisolism Cushing Like Syndrome - from exogenous cortisone 1. Etiology 2. Clinical manifestations moon face, buffalo hump and truncal obesity glucose intolerance, osteoporosis, thin hair, purple striae, large abdomen, acne, facial hair, hyperpigmentation, thin extremities, altered affect, infections 3. Diagnosis urinary free cortisol levels, dexamethasone suppression test 4. Treatment cause, steroids, surgery, radiation B. Adrenal Hyperfunction - mineralocorticoid - Hyperaldosteronism excessive aldosterone secretion by the adrenal gland 1. Primary aldosteronism (Conn Disease) a. Etiology adrenal cortex pathology b. Clinical manifestations hypertension, renal K+ wasting c. Pathophysiology sodium reabsorption with hypervolemia 7
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

2. Secondary hyperaldosteronism a. Etiology b. Pathophysiology (secondary hyperaldosteronism) increased circulating blood volume from renin secretion 3. Clinical manifestations hypertension, hypokalemia 4. Diagnosis BP, electrolytes, aldosterone levels, aldosterone suppression test 5. Treatment C. Adrencortical Hypofunction inadequate stimulation of the adrenal glands by ACTH decreased production of cortical hormones by the adrenal gland 1. Primary adrenal cortical insufficiency - Addison Disease a. Etiology b. Pathophysiology elevated ACTH levels with low corticosteroid levels c. Clinical manifestations weakness and fatigue, anorexia, NVD, hypoglycemia, mental changes hyperpigmentation, hypotension d. Diagnosis serum cortisol levels, aldosterone and 17 ketosteroid depression e. Treatment hormone replacement and diet D. Adrenal Medulla Hyperfunction - Pheochromacytoma 1. Etiology catecholamine producing tumore of adrenal medulla 2. Pathophysiology norepinephrine production 3. Clinical manifestations hypertension, flushing, diaphoresis, tachycardia, palpitations, sweating 4. Diagnosis serum and urine catecholamine levels 5. Treatment surgery 8
Image of page 8
E. Adrenal Medulla Hypofunction - rare - post adrenalectomy rbe rbe spring 2018 9
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern