Increased Epogen = - Increased bone pain - Sternal tenderness 73 . Causes of Leukocytosis - increased WBC's - Infectious organisms - Exercise - Emotional changes - Temp changes - Anesthesia, surgery - Pregnancy - Drugs - Hormones - Toxins 74 . Alterations of Leukocytes - can be quantitative Quantitative 1. Bone marrow dysfunction 2.Premature destruction of cells a. May originate in lymphoid organs secondary to infectious process 75 . Leukocytosis is a defense mechanism... - Absolute Leukocyte count that is HIGHER than normal - Absolute neutrophil count is greater than 7500 - Neutrophils become so few that they cannot defend your body 76 . Leukopenia - Never normal or beneficial - Defined as as an absolute blood cell count less than 4000 cells/mm3 77 Pathologic Leukocytosis - From Malignancies
. - Hematologic disorders such as Myelotic leukemia having an absolute neutrophil count greater 100,000/microliters which * Increases the viscosity of the blood and the risk of thrombus formation 78 . Neutropenia - Defined as neutrophil count 200/microliter Low count of Neutrophils which destroy bacteria. 79 . Causes of Neutropenia - Severe prolonged infection - Aplastic anemia - leukemia - Drug or Toxin induced - Starvation / anorexia nervosa 80. Neutropenia is a classic s/s of what? 81. Severe Neutropenia [Granulocytopenia or Agranulocytosis]Called [Granulocytopenia or Agranulocytosis] which causes: - Increased cell destruction in circulation from: b.Drugs: NSAIDS and anti-thyroid drugs 82 . Agranulocytosis can be a complication of what? 83 . S/S of Severe Neutropenia - Malaise - Septicemia - Fever - Tachycardia - Ulcerations in the mouth/colon - Death if untreated 84 . Eosinophilia - Greater than 450/microliter - Caused by: - Allergic disorders - Atopic dermatitis - Eczema - Pemphigus - Scleroderma - Parasitic infestation 85 . 1st thing to think about when you have a pt with watery diarrhea and Eosinophilia? - Gastroenteritis from a parasitic infection 86 . Basophilia - Too many Basophils - Response to inflammation/hypersensitivity - Contain histamines - Caused by: - Myeloproliferative disorders like - CML - Meyloid metaplasia = basophilia
87 . Basopenia [HASO] - Too few basophils - Caused by: - Hyperthyroidism - Acute infection - Long-term steroid therapy - Ovulation and pregnancy 88 . Lymphocytes and Infectious Mononucleosis [Mono) - Acute - Self-limiting - Neoplastic lymphoproliferative syndrome - Infection of B lymphocytes - From the EBV - Etiology: viral transmission, oral/fecal 89 . Lymphocytes and Infectious Mononucleosis - Incubation period is 30-60 days - Diagnosed with blood tests - Monospot may be false positive) - Heterophilic antibody test is the MOST ACCURATE way to dx Mononucleosis - HAT test 90 . Leukemia - Clonal malignant disorder of blood / blood forming organs - Accumulation of dysfunctional cells - Loss of cell division regulation causing uncontrolled proliferation of leukocytes which: - causes overcrowding of bone marrow - and decreased production and function of normal hematopoietic cell 91 .
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- Fall '17
- keisha lovence