W1L1 Introduction to Evolution.pdf

Huge population size lots of opportunity for mutation

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-- Huge population size = lots of opportunity for mutation -- High mutation rate = lots of variation -- Short generation time = large number of generations -- Strong selection (big differences in fitness) - Partial solution: drug cocktails -- Require more mutations to confer resistance -- A mutation that increases the resistance to one drug may make the virus more susceptible to another drug (i.e., a fitness Trade-off ) - Some individuals are resistant to HIV infection. -- In Europe, most resistant individuals are homozygous for an allele that codes for the receptor CCR5, but has a 32 base pair deletion: CCR5- Δ 32 Genetic Resistance to HIV Distribution of CCR5- Δ 32 Evolution is an historical science Pattern vs. process Chronicle vs. narrative Proximate vs. ultimate causation Diverse approaches to research –Hypothetical-deductive method –Descriptive work –Phylogenetic comparative methods –Mathematical models
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Big Picture Objectives 1. Variation and Diversity matter Big Picture Objectives 1. Variation and Diversity matter 2. Evolution is an historical science If the 4.6 billion years of the earth = 1 hour - First 50 minutes is a history of microbes - Animal life takes up the last 10 minutes - Human history & civilization takes the last 1/100 of a second Big Picture Objectives 1. Variation and Diversity matter 2. Evolution is an historical science 3. Power & limits of evolutionary change - No ultimate goal in evolution - The concept of progress in evolution is not appropriate Teleology : The doctrine of final causes, i.e., that natural & historical processes are determined by their ultimate purpose. Evolution does not work this way. - Evolution tinkerers , is not an engineer. Thus, evolution is full of historical contingencies , and much is not possible.
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Big Picture Objectives 1. Variation and Diversity matter 2. Evolution is an historical science 3. Power & limits of evolutionary change 4. Understand the relevance of evolution to contemporary issues Big Picture Objectives 1. Variation and Diversity matter 2. Evolution is an historical science 3. Power & limits of evolutionary change 4. Understand the relevance of evolution to contemporary issues 5. Make your next walk in the woods a richer experience The End
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