No transmits messages between nerve cells associated

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• NO transmits messages between nerve cells; associated with the process of learning, memory, sleeping, feeling pain, and maybe even depression. • NO has been shown to be a mediator in inflammation and rheumatism.
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-There are many ways of stimulating NO signaling in body but all involve the activity of nitric oxide synthase (NOS) -In neurons, NO is released from neurons upon the stimulation of nitric oxide synthase (NOS) in response to NMDA receptor activation -3 genes encode the 3 NOS isoforms in the body: nNOS is exclusively in neurons, endothelial NOS ( eNOS ) in endothelial cells and inducible NOS (iNOS) in immune cells; both eNOS and iNOS can be found in neurons -nNOS is activated by Ca2+-calmodulin binding (activated upon Ca2+ entry through the NMDA receptor) and converts arginine to NO NO Synthesis
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