• NO transmits messagesbetween nerve cells; associated with the process of learning, memory, sleeping, feeling pain, and maybe even depression. • NO has been shown to be a mediatorin inflammation and rheumatism.
has intentionally blurred sections.
Sign up to view the full version.
-There are many ways of stimulating NO signaling in body but all involve the activity of nitric oxide synthase (NOS)-In neurons, NO is released from neurons upon the stimulation of nitric oxide synthase (NOS)in response to NMDA receptor activation-3 genes encode the 3 NOS isoforms in the body: nNOSis exclusively in neurons, endothelial NOS (eNOS) in endothelial cells and inducible NOS (iNOS) in immune cells; both eNOS and iNOS can be found in neurons-nNOS is activated by Ca2+-calmodulin binding(activated upon Ca2+ entry through the NMDA receptor)and converts arginineto NONO Synthesis