PHRM 514 STD's Fall 2012 (1)

Sexually transmitted disease surveillance 2010

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Unformatted text preview: Sexually Transmitted Disease Surveillance 2010. Atlanta: U.S. Department of Health and Human Services; 2011. Genital Herpes n Caused by the herpes simplex virus (HSV) § Type 1—usually associated with “cold sores” § Type 2—usually associated with genital herpes n Transmitted when infected secretions come in contact with mucosal surfaces: § Urethra § Oropharynx § Cervix § Conjunctivae or abraded skin Knodel, LC. Sexually transmitted diseases. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:2011-2028. Genital Herpes: Pathophysiology n Virus replicates in skin and mucus membranes at site of infection n 5 Stages 1. Primary mucocutaneous infection 2. Infection of the ganglia 3. Establishment of latency 4. Reactivation 5. Recurrent infection Knodel, LC. Sexually transmitted diseases. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:2011-2028. Genital Herpes n Incubation period = 2 to 14 days n Primary—1st episode § Initial genital infection § Seronegative for antibodies to HSV-1 or 2 n Non-primary—1st episode § Initial genital infection § Clinical or serologic evidence of prior HSV § Usually HSV-1 n Recurrent § 2nd or subsequent outbreaks Knodel, LC. Sexually transmitted diseases. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:2011-2028. Genital Herpes: Symptoms— 1st Episode Infections n Eruption of multiple pustular or ulcerative lesions on external genitalia § Develop over 7 to 10 days § Heal within 2 to 4 weeks n Itching, pain in the genital area, fever, headache, malaise, vaginal or urethral discharge, tender inguinal adenopathy, urine retention, parasthesias n Viral shedding § 11-12 days for primary § 7 days for non-primary Knodel, LC. Sexually transmitted diseases. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:2011-2028. Genital Herpes Picture of herpes simplex virus type 2. Emedicinehealth. http://www.emedicinehealth.com/script/main/art.asp? articlekey=120860. Accessed October 23, 2011. Genital Herpes: Symptoms— Recurrent n Prodrome —itching, burning, or tingling at the site of future lesions n Fewer lesions n More localized n Shorter duration (Heal within 7 days) n Milder symptoms n Viral shedding ~4 days *Asymptomatic viral shedding can occur during 1st episode or recurrent episodes* Knodel, LC. Sexually transmitted diseases. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy a Knodel, LC....
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Sexually Transmitted Disease Surveillance 2010 Atlanta U.S...

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