PHRM 514 STD's Fall 2012 (1)

Membranes at site of infection n 5 stages 1 primary

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membranes at site of infection n 5 Stages 1. Primary mucocutaneous infection 2. Infection of the ganglia 3. Establishment of latency 4. Reactivation 5. Recurrent infection Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028.
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Genital Herpes n Incubation period = 2 to 14 days n Primary—1st episode § Initial genital infection § Seronegative for antibodies to HSV-1 or 2 n Non-primary—1st episode § Initial genital infection § Clinical or serologic evidence of prior HSV § Usually HSV-1  n Recurrent § 2nd or subsequent outbreaks Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028.
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Genital Herpes:  Symptoms— 1st Episode Infections n Eruption of multiple pustular or ulcerative lesions on  external genitalia § Develop over 7 to 10 days § Heal within 2  to 4 weeks n Itching, pain in the genital area, fever, headache,  malaise, vaginal or urethral discharge, tender inguinal  adenopathy, urine retention, parasthesias n Viral shedding § 11-12 days for primary § 7 days for non-primary Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028.
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Genital Herpes Picture of herpes simplex virus type 2.  Emedicinehealth.  ? articlekey=120860.  Accessed October 23, 2011.  
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Genital Herpes:  Symptoms— Recurrent n Prodrome —itching, burning, or tingling at the  site of future lesions n Fewer lesions n More localized n Shorter duration (Heal within 7 days) n Milder symptoms n Viral shedding ~4 days *Asymptomatic viral shedding can occur during 1st  episode or recurrent episodes* Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028.
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Genital Herpes:  Complications n Lesions at extragenital sites § Eye § Rectum § Pharynx § Fingers n CNS involvement Knodel, LC.  Sexually transmitted diseases.  In:  DiPiro JT, Talbert RL, Yee GC, et al., editors.  Pharmacotherapy a  pathophysiologic approach.  8th ed.  New York:  McGraw Hill Medical; 2011:2011-2028.
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Neonatal Herpes n High morbidity and mortality § Fatality rate of 50% n Transmitted via exposure to HSV in the birth  canal § Rarely transplacentally n Risk greater for 1st episode primary  infections n
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