Rare genetic disorder urbach wiethe disease the

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Rare genetic disorder: Urbach-Wiethe Disease The Amygdala is involved in recognition of facial expressions, especially fear
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Post-Traumatic Stress Disorder Post-Traumatic Stress Disorder ! PTSD patients ! Impaired at Extinction ! Even when a stimulus no longer predicts a shock, it still yields a response ! In Skin Responses ! In Amygdala ! In vmPFC
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A fear response can be evoked through both a ± high ² and a ± low ² pathway Perception of fear without awareness Very Brief (17ms) masked stimuli
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Perception of fear without awareness Perception of fear without awareness
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Emotional effects on the attentional blink paradigm Fear-enhanced processing of faces in the fusiform gyrus is reduced in patients with amygdala damage
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! Facial Expressions ! Anatomy of Emotion ! Fear ! Emotion and Memory ! Other Emotions Agenda There is a double dissociation between Amygdala and Hippocampus damage for fear conditioning Patient S.P. ! S.P. knew that the square would lead to a shock, but did not show implicit memory ! Patients with Hippocampal damage show implicit memory without the learned explicit knowledge
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The Amygdala is involved in both implicit and explicit emotional memory ! For both implicit and explicit fear learning, the Amygdala is required for the fear response Flashbulb Memory Very vivid memory of a powerful event An Episodic memory. Very Detailed. ± Indelible ² ? Ex: Sept 11 Terrorist attacks, Earthquake Princess Diana ³ s Death, Challenger Explosion, JFK Assassination, Pearl Harbor Can also be a personal event - family tragedy, etc More likely to occur when event is: • Important, • Surprising, & has Emotional Impact Evidence that emotional content is important for memory
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Strong emotional arousal can enhance long-term memory ! Amygdala improves long term memory in three ways: ! Increases subjective richness, contextual details (Dolcos et al. 2004) !
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