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Moa promotes anti inflammatory and cytoprotective

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MOA:promotes anti-inflammatory and cytoprotective activitiesthrough the Nrf2 pathway
PTIV Exam 5Indicated for CIS, RRMS, SPMSDI: live vaccinesLimited pregnancy dataSE: flushing (improves with continued use, can use ASA 30 min before dose),Abdominal pain, D, N, increased risk of infection, hepatotoxicity, skin rash,pruritis, hypersensitivity rxns (at any time)Warnings: anaphylaxis, angioedema, PML, lymphopeniaMonitor: CBC with diff before & every 6 months, LFTs at baseline duringTake with Food to reduce GI sxDiroximalFumarateBioequivalent to dimethyl fumaratemetabolized to monomethyl fumarateMOA:promotes anti-inflammatory and cytoprotective activitiesthrough the Nrf2 pathwayApproved for CIS, RRMS, SPMSDI: live vaccinesAVOID in pregnancySE: flushing, abdominal pain, D, N (GI SE less than dimethyl fumarate),infections, hepatotoxicityWarnings: PML, lymphopeniaIf administering with food, limit fat to <30 g & calories to <700Monitor: CBC with diff before & every 6 months, LFTs at baseline duringMonomethylFumarateBioequivalent to dimethyl fumarate (active metabolite)Delayed release capsules availableMOA:promotes anti-inflammatory and cytoprotective activitiesthrough the Nrf2 pathwayApproved for CIS, RRMS, SPMSDI: Avoid live vaccine sSE: flushing (may use ASA 30 min before), abdominal pain, D, N, anaphylaxis,angioedema, infection,hepatotoxicityWarnings: PML, lymphopeniaMonitor: CBC with diff before & every 6 – 12 months, LFTs at baseline duringFingolimodMOA: Binds to sphingosine 1-phosphate receptors and blocks the ability oflymphocytes to emerge from lymph nodesdec # of lymphocytes availableto the CNSIndicated for CIS, RRMS, SPMSFirst dose, and any doses following a 14+ day therapy interruptionshould be administered in a physician’s officeRisk of fetal harmcontraceptives during & 2 months after txSE: lymphopenia, infections,HA, abdominal pain, D, inc LFTs, pain in arms,legs, back, dec respiratory function,macular edema(Avoid in diabetes),HTNWarnings:bradycardia, AV block(CI in pts with recent CV events &antiarrhythmics),PML,posterior reversible encephalopathy syndrome(PRES)– sudden onset of HA, AMS, visual disturbances, seizures911!Monitor: CBC w/ diff, LFTs, ECGSiponimodMOA: more selective than fingolimodsphingosine 1 phosphate receptormodulatorFirst doseGIVE in physician’s officeIndicated for CIS, RRMS, SPMSContraceptives during & 10 days after therapySE: lymphopenia, infections, HA, inc LFTs,macular edema,HTN, decrespiratory functionsWarnings:bradycardia, AV block(CI with recent CV event & pts withCYP2C9*3/*3genotype)
PTIV Exam 5Monitor: CBC w/ diff, LFTs, ECGNOT to use after tx with alemtuzumabOzanimodMOA: sphingosine 1-phosphate receptor modulatorApproved for CIS, RRMS, SPMSContraceptives during & 3 months after therapySE: lymphopenia, infections, HA, inc LFTs,macular edema, HTN, decrespiratory functions, back pain, orthostatic hypoTNWarnings:bradycardia & AV block(CI with recent CV events or sleepapnea),PML, PRESbradycardia NOT as severe as previous agentsDONOT NEED OFFICE ADMINMonitor: CBC w/ diff, LFTs, ECGContraindicated with monoamine oxidase inhibitors (MAOIs)TeriflunomideMOA: inhibits pyrimidine synthesisCytostatic effect on rapidly dividing T-and B-lymphocytes in the peripheryIndicated for CIS, RRMS, SPMSDI: immunosuppressants, vaccinesCI in pregnancymust have negative pregnancy test before starting

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Term
Fall
Professor
professor_unknown
Tags
The Grave, Neuroimaging

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