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04 Cell Membranes and Signaling

Cannot overcome inhibition receptor ligand ligand

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Cannot Overcome Inhibition [Receptor-Ligand] Ligand Concentration Control (No Inhibitor) Presence of Inhibitor
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Lipid Soluble Messengers Pass Through Cell Membrane and Bind to Intracellular Receptors
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Water-Soluble Messengers Bind to Cell Surface Receptors - Coupled to Signaling Pathways
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Major Mechanisms of Receptor-Coupled Cell Signaling (a) Receptor Ion Channel (b) Receptor Tyrosine Kinase (c) Receptor JAK Kinase (d) G-Protein-Coupled Receptor
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Receptor Ion Channel is a Major Signaling Mechanism at the Neuromuscular Junction
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Receptor-JAK Kinase Signaling is a Major Signaling Mechanism for Inflammatory Cytokines (From: J Immunol 178: 2623-2629, 2007)
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G-Protein-Coupled Receptor -Mediated Activation of Adenylyl Cyclase Leads to the Production of Cyclic AMP and Activation of Protein Kinase A
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Cascade of Enzyme Phosphorylation and Activation is a Major Mechanism of Signal Amplification
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G-Protein-Coupled Receptor -Mediated Activation of Phospholipase C Produces Two Intracellular Messengers: 1. Inositol Trisphosphate (IP3) for Releasing Ca2+ from Endoplasmic Reticulum 2. Diacylglyceral (DAG) for Activating Protein Kinase C
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Ca2+ Functions as an Second Messenger in Cell Signaling By Activating Ca2+-Calmodulin-Dependent Kinases
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