Did a study on chemicals structurally similar to

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Did a study on chemicals structurally similar to adrenaline and tested their effects on sympathetic nerve responses 4. Acetylcholine 1913 a. Acetylcholine was naturally synthesized in 1813 in the WPRL by Dale b. Dale later did a paper on the pharmacology of choline derivatives and found two principal effects of acetylcholine, one that could be reproduced by injections of muscarine and one reproduced by nicotine c. 1914 there was little evidence showing for acetylcholine’s physiological significane and further research declined after wartime d. But the work was undertaken by the University of Graz in 1920 5. Acetylcholine 1921-1929 a. Austrian pharmacologist Otto Loewi discovered a chemical that he called vagusstoff, which turned out to be a choline derivative, sparking a new interest in the possibility of chemical involvement in neural functioning b. Still there was no proof that acetylcholine occurred naturally in the animal body, as Dale mentioned it was hard to overcome the technical difficulties c.
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  • Spring '17
  • Robert Frank
  • Henry Dale

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