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21 what are three major types of syndromes seen in

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21. What are three major types of syndromes seen in Arbovirus infections? Why?
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Lecture Guide 10 1. What are the two classes of parasites we discussed this week? How are they classified within their respective groups and what are a few examples of each type? 2. What are some of the general characteristics of disease caused by parasites? 3. What are zoonoses? 4. What is the difference in a vector and a reservoir? 5. What are the general characteristics of Sporozoa? 6. In what regions of the world is malaria found? Why? 7. What types of cases are seen in the US? 8. What are the 4 species of the malarial parasite we discussed and how do they different in term of morphology and disease? 9. What is heterozygote advantage? Describe this in relation to sickle cell anemia and infection with the parasite. 10. What type of mosquito transmits the disease? What behaviors make for the most dangerous species in terms of transmission? 11. Describe the malarial life cycle. How is the cycle in the human different from that in the mosquito? 12. Describe the pathogenesis of malaria and relate this to the clinical manifestations of disease. 13. We discussed several diagnostic techniques. Describe them and comment on any of the benefits or drawbacks of each. 14. What are some of the special considerations used in the design of a rapid diagnostics test for malaria? 15. What are some of the drugs used to treat infections? 16. What are two reasons that combination therapies used in treatment? 17. Why is vaccine development difficult? 18. Take a minute to review the data that was presented on the receptor for PfRh5.
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19. What are kinetoplastids? What distinguishing feature do they have? What are the classes that are pathogens to humans? 20. What are the 4 morphological forms of kinetoplasts? 21. What are the two forms of Trypanosomiasis we discussed? In broad terms how do they differ? 22. How are African trypanosomes transmitted? 23. Why are there two forms of African Sleeping Sickness? 24. What are the differences between the two forms? Speak to transmission and pathogenesis. 25. What is Nagana? 26. Describe the T. brucei life cycle? 27. Why is there a difference in the mitochondrial function in the trypomastigote versus the promastigote (procyclic?) 28. Describe the pathogenesis and clinical manifestations of both forms of Sleeping Sickness. 29. What is VSG and how does its changing expression pattern result in the periodic raise and fall of parasitemia? 30. How is a trypanosomal infection diagnosed and how is an infection treated? 31. What is Chagas disease? Where is it found and what is the causative agent? 32. Describe the life cycle of T. cruzi. How does it differ from T. brucei? 33. Describe the pathogenesis and clinical manifestations of infection with T. cruzi. 34. How is an infection diagnosed and treated? Why is there a problem with transmission by blood transfusions?
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