Monitor closely. Salicylic acid Uricosuric Effect of probenemide, sulfinpyrazone, and phenyl-butazone inhibited Monitor closely. Salicylic acid Pyrazinamide Pyrazinamide-induced hyperuricemia inhibited Monitor closely; may consider alternative acne agent.
Pharmacologic Treatment of Acne: Sulfur ± Resorcinol • Sulfur 3% – 10% • Keratolytic and antibacterial • Adverse effects (rare): noticeable odor and dry skin, depending on the formulation used; resorcinol produces a reversible, dark brown scale on some darker-skinned individuals
Pharmacologic Treatment of Acne: Comparison of Properties Agent Antibacterial Comedolytic Anti-inflammatory Keratolytic Adapalene 0.1% No Yes Yes Yes Benzoyl peroxide 2.5% – 10% Yes Yes No Yes Salicylic acid 0.5% – 2% No Yes Yes No Sulfur 3% – 10% Yes No No Yes Resorcinol 2% with sulfur 3% – 8% Yes No No Yes Resorcinol monoacetate 3% with sulfur 3% – 8% Yes No No Yes
Pharmacologic Treatment of Acne: Product Selection • Gels most effective • Lotions and creams may help counteract drying — good alternative to gels • Cleansing products less effective because less product left on the skin • Cream formulations may be better for fair skinned individuals, while gels may be better for darker complexions
Treatment of Acne: Special Populations • Pregnancy DISCONTINUE medication and advise obstetrician of current or previous product use because of the potential for teratogenic effects • Pediatrics avoid use of aspirin and aspirin-containing products, such as salicylic acid, in children or teenagers who have or are recovering from chicken pox or flu-like symptoms risk of Reye’s syndrome
Treatment of Acne: CAM • Limited data exist regarding safety and efficacy • Tea tree oil antibacterial, antifungal, anti-inflammatory • Oral zinc bacteriostatic alternative to tetracyclines • Vitamin A naturally occurring retinol • Nicotinamide anti-inflammatory
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- Fall '13
- Head louse, Pediculosis, Body louse, acne, Acneiform eruptions